Recombinant Anti-PSEN1 Vesicular Antibody, EV Displayed (VS-0425-YC91) (CAT#: VS-0425-YC91)

• Application
• ELISA, FC, Cell-uptake

• Product Type
• Ab-Fc-EVs

• Antibody Quantification (Ab/EV)
• ~100 Ab/EV

• Target
• PSEN1

• Host Animal
• Rabbit

• Antibody Isotype
• IgG

• Species Reactivity
• Human

• Expression Cell
• Mammalian cell

• EV-sorting domain
• CD63

• Fc-binding domain
• Protein A

• EV Size
• 30~150 nm

• Producing Cell
• HEK293F

• Isolation Method
• Gradient centrifugation

• Purification
• qEV size exclusion chromatography

• Concentration
• 1 x 10¹⁰

• Size
• 1 mL

• Buffer
• PBS

• Storage
• Store at -80°C for 12 months

• Full Name
• Presenilin 1

• Biological Process
• Apoptosis, Cell adhesion, Notch signaling pathway

• Molecular Function
• Hydrolase, Protease

• Cellular Localization
• Golgi apparatus, Nucleoplasm, Cell Junctions

• Introduction
• Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes.

• Alternative Names
• AD3; FAD; PS1; PS-1; S182; CMD1U; PSNL1; ACNINV3

• Gene ID
• 5663

• UniProt ID
• P49768

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