Recombinant Rabbit Anti-S100A12 Capture Antibody (clone R93-1A-3) (CAT#: VS3-WK1920)
This antibody is a rabbit recombinant antibody against human S100A12. It was developed by immunization of rabbit with recombinant human S100A12 protein and then was produced as a recombinant antibody. The isotype of this product is rabbit IgG. The sandwich ELISA was established using matched antibody pair R93-1A-3 and R13-8Q-7. The clone R93-1A-3 can be used as a capture antibody in ELISA analysis to identify human S100A12.
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Normal Tissue
RNA Expression
Figure 1 High expression in bone marrow
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2881/9436_B_5_4_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2881/9436_B_5_4_val_selected.jpg
Figure 2 Low expression in cerebral cortex
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2881/9436_B_8_5_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2881/9436_B_8_5_val_selected.jpg
Figure 3 Bone marrow
(Hematopoietic cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2881/9436_B_5_4.jpg
(Hematopoietic cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2881/9436_B_5_4.jpg
Figure 4 Lymph node
(Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2881/9436_A_8_8.jpg
(Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2881/9436_A_8_8.jpg
Figure 5 RNA cell line category: Cell line enhanced (hTCEpi, THP-1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000163221-S100A12
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000163221-S100A12
Specifications
- Immunogen
- Recombinant human S100A12 protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human S100A12
- Species Reactivity
- Human
- Clone
- R93-1A-3
- Applications
- ELISA
- Conjugate
- Unconjugated
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Aggregation
- < 5%
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 0.01M PBS, pH 7.2
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- S100 Calcium Binding Protein A12; Extracellular Newly Identified RAGE-Binding Protein; Migration Inhibitory Factor-Related Protein 6; Calcium-Binding Protein In Amniotic Fluid 1; Neutrophil S100 Protein; EN-RAGE; CAAF1; MRP-6; CGRP; CAGC; P6
- Gene ID
- 6283
- UniProt ID
- P80511
- Long Name
- S100 Calcium Binding Protein A12
- Sequence Similarities
- Belongs to the S-100 family.
- Cellular Localization
- Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Secreted
- Protein Refseq
- NP_005612.1
- Function
- S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its pro-inflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "S100A12"
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IgG Antibody Products
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IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3925z | Mouse Anti-S100A12 Recombinant Antibody (clone 13G3) | WB, ELISA, IHC | Mouse IgG1, κ |
| MOB-1450MZ | Recombinant Mouse Anti-Human S100A12 Antibody (clone 20G6) | WB | Mouse antibody |
| VS3-WK1921 | Recombinant Rabbit Anti-S100A12 Detection Antibody (clone R13-8Q-7) | ELISA | Rabbit IgG |
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