Recombinant Rabbit Anti-S100A12 Capture Antibody (clone R93-1A-3) (CAT#: VS3-WK1920)
This antibody is a rabbit recombinant antibody against human S100A12. It was developed by immunization of rabbit with recombinant human S100A12 protein and then was produced as a recombinant antibody. The isotype of this product is rabbit IgG. The sandwich ELISA was established using matched antibody pair R93-1A-3 and R13-8Q-7. The clone R93-1A-3 can be used as a capture antibody in ELISA analysis to identify human S100A12.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 High expression in bone marrow
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2881/9436_B_5_4_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2881/9436_B_5_4_val_selected.jpg
Figure 2 Low expression in cerebral cortex
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2881/9436_B_8_5_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2881/9436_B_8_5_val_selected.jpg
Figure 3 Bone marrow
(Hematopoietic cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2881/9436_B_5_4.jpg
(Hematopoietic cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2881/9436_B_5_4.jpg
Figure 4 Lymph node
(Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2881/9436_A_8_8.jpg
(Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2881/9436_A_8_8.jpg
Figure 5 RNA cell line category: Cell line enhanced (hTCEpi, THP-1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000163221-S100A12
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000163221-S100A12
Specifications
- Immunogen
- Recombinant human S100A12 protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human S100A12
- Species Reactivity
- Human
- Clone
- R93-1A-3
- Applications
- ELISA
- Conjugate
- Unconjugated
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Aggregation
- < 5%
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 0.01M PBS, pH 7.2
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- S100 Calcium Binding Protein A12; Extracellular Newly Identified RAGE-Binding Protein; Migration Inhibitory Factor-Related Protein 6; Calcium-Binding Protein In Amniotic Fluid 1; Neutrophil S100 Protein; EN-RAGE; CAAF1; MRP-6; CGRP; CAGC; P6
- Gene ID
- 6283
- UniProt ID
- P80511
- Long Name
- S100 Calcium Binding Protein A12
- Sequence Similarities
- Belongs to the S-100 family.
- Cellular Localization
- Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Secreted
- Protein Refseq
- NP_005612.1
- Function
- S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its pro-inflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER).
Recommended Products
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
Rabbit Monoclonal Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3925z | Mouse Anti-S100A12 Recombinant Antibody (clone 13G3) | WB, ELISA, IHC | Mouse IgG1, κ |
| MOB-1450MZ | Recombinant Mouse Anti-Human S100A12 Antibody (clone 20G6) | WB | Mouse antibody |
| VS3-WK1921 | Recombinant Rabbit Anti-S100A12 Detection Antibody (clone R13-8Q-7) | ELISA | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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