Recombinant Rabbit Anti-S100A12 Detection Antibody (clone R13-8Q-7)
CAT#: VS3-WK1921
This antibody is a rabbit recombinant antibody against human S100A12. It was developed by immunization of rabbit with recombinant human S100A12 protein and then was produced as a recombinant antibody. The isotype of this product is rabbit IgG. R93-1A-3 and R13-8Q-7 were identified as antibody pair for sandwich ELISA. As a detection antibody, the clone R13-8Q-7 can be used in ELISA analysis to identify human S100A12.
Gene Expression
Normal Tissue
Figure 1 High expression in bone marrow
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2881/9436_B_5_4_val_selected.jpg
Normal Tissue
Figure 2 Low expression in cerebral cortex
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2881/9436_B_8_5_val_selected.jpg
Normal Tissue
Figure 3 Bone marrow
Hematopoietic cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2881/9436_B_5_4.jpg
Normal Tissue
Figure 4 Lymph node
Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2881/9436_A_8_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (hTCEpi, THP-1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000163221-S100A12
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Specifications
- Immunogen
- Recombinant human S100A12 protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human S100A12
- Species Reactivity
- Human
- Clone
- R13-8Q-7
- Applications
- ELISA
- Conjugate
- Unconjugated
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Aggregation
- < 5%
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 0.01M PBS, pH 7.2
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- S100 Calcium Binding Protein A12; Extracellular Newly Identified RAGE-Binding Protein; Migration Inhibitory Factor-Related Protein 6; Calcium-Binding Protein In Amniotic Fluid 1; Neutrophil S100 Protein; EN-RAGE; CAAF1; MRP-6; CGRP; CAGC; P6
- Gene ID
- 6283
- UniProt ID
- P80511
- Long Name
- S100 Calcium Binding Protein A12
- Sequence Similarities
- Belongs to the S-100 family.
- Cellular Localization
- Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Secreted
- Protein Refseq
- NP_005612.1
- Function
- S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its pro-inflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of pro-inflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn2+ from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Capture antibody
Isotype Control
- CAT
- Product Name
Secondary Antibody
See other products for "S100A12"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3925z | Mouse Anti-S100A12 Recombinant Antibody (clone 13G3) | WB, ELISA, IHC | Mouse IgG1, κ |
| MOB-1450MZ | Recombinant Mouse Anti-Human S100A12 Antibody (clone 20G6) | WB | Mouse antibody |
| VS3-WK1920 | Recombinant Rabbit Anti-S100A12 Capture Antibody (clone R93-1A-3) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4399 | Hi-Affi™ Recombinant Rabbit Anti-S100A12 Monoclonal Antibody (SI490DS) | IHC-P | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1989 | Anti-S100A12 Immunohistochemistry Kit | IHC | |
| VS-0525-XY6297 | Anti-Human S100A12 Immunohistochemistry Kit | IHC |
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