Recombinant Anti-SCARB1 Vesicular Antibody, EV Displayed (VS-0425-YC516) (CAT#: VS-0425-YC516)
The Recombinant Anti-SCARB1 Vesicular Antibody, EV Displayed (VS-0425-YC516) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to SCARB1-expressed cells or tissues. SCARB1 is a protein that serves as a plasma membrane receptor for high-density lipoprotein cholesterol (HDL). The protein facilitates cholesterol transfer to and from HDL and is also a receptor for hepatitis C virus glycoprotein E2.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles & lysosomes.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/66285/1250_H7_5_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles & lysosomes.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/66285/1250_H7_5_selected.jpg
Figure 2 Adrenal gland
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/70124/166148_B_4_5_val_selected.jpg
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/70124/166148_B_4_5_val_selected.jpg
Figure 3 Kidney
(Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/72449/166126_A_7_5.jpg
(Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/72449/166126_A_7_5.jpg
Figure 4 Testis
(Leydig cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/72449/166126_A_4_6.jpg
(Leydig cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/72449/166126_A_4_6.jpg
Figure 5 RNA cell line category: Cell line enhanced (RPMI-8226)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000073060-SCARB1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000073060-SCARB1
Recombinant Antibody
- Application
- ELISA, FC, Neut, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- SCARB1
- Host Animal
- Human
- Antibody Isotype
- IgG4
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 1.84 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Scavenger receptor class B member 1
- Biological Process
- Host-virus interaction
- Molecular Function
- Host cell receptor for virus entry, Receptor
- Cellular Localization
- Vesicles, Lysosomes, Rods & Rings
- Introduction
- The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]
- Alternative Names
- CD36L1, CLA-1, CLA1, SR-BI, SRB1
- Gene ID
- 949
- UniProt ID
- Q8WTV0
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1865z | Mouse Anti-SCARB1 Recombinant Antibody (clone 4H1) | WB, ICC, IF, IHC | Mouse IgG1 |
| HPAB-1609-FY | Recombinant Human Anti-SCARB1 Antibody (HPAB-1609-FY) | Inhib, Neut, FC | Human IgG4 |
| HPAB-1610-FY | Recombinant Human Anti-SCARB1 Antibody (HPAB-1610-FY) | Inhib, FC | Human IgG |
| HPAB-1611-FY | Recombinant Human Anti-SCARB1 Antibody (HPAB-1611-FY) | Inhib, Neut, FC | Human IgG4 |
| VS3-FY1321 | Recombinant Rabbit Anti-SCARB1 Antibody (clone R06-6H2) | WB | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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