Recombinant Anti-SCARB1 Vesicular Antibody, EV Displayed (VS-0425-YC516)

CAT#: VS-0425-YC516

The Recombinant Anti-SCARB1 Vesicular Antibody, EV Displayed (VS-0425-YC516) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to SCARB1-expressed cells or tissues. SCARB1 is a protein that serves as a plasma membrane receptor for high-density lipoprotein cholesterol (HDL). The protein facilitates cholesterol transfer to and from HDL and is also a receptor for hepatitis C virus glycoprotein E2.

Gene Expression
Figure 1 IF staining of human cell line U-2 OS Figure 2 Adrenal gland Figure 3 Kidney Figure 4 Testis Figure 5 RNA cell line category: Cell line enhanced (RPMI-8226)

Recombinant Antibody

  • Application
  • ELISA, FC, Neut, Cell-uptake
  • Product Type
  • Ab-Fc-EVs
  • Antibody Quantification (Ab/EV)
  • ~100 Ab/EV
  • Target
  • SCARB1
  • Host Animal
  • Human
  • Antibody Isotype
  • IgG4
  • Species Reactivity
  • Human
  • Expression Cell
  • Mammalian cell

Engineered EVs

  • EV-sorting domain
  • CD63
  • Fc-binding domain
  • z domain
  • EV Size
  • 30~150 nm
  • Producing Cell
  • HEK293F
  • Isolation Method
  • Gradient centrifugation
  • Purification
  • qEV size exclusion chromatography
  • Binding Affinity
  • Kd = 1.84 µg/mL
  • Concentration
  • 1 x 10¹⁰
  • Size
  • 1 mL
  • Buffer
  • PBS
  • Storage
  • Store at -80°C for 12 months

Target

  • Full Name
  • Scavenger receptor class B member 1
  • Biological Process
  • Host-virus interaction
  • Molecular Function
  • Host cell receptor for virus entry, Receptor
  • Cellular Localization
  • Vesicles, Lysosomes, Rods & Rings
  • Introduction
  • The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]
  • Alternative Names
  • CD36L1, CLA-1, CLA1, SR-BI, SRB1
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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