Recombinant Anti-SEMA4A Vesicular Antibody, EV Displayed (VS-0425-YC155)
CAT#: VS-0425-YC155
The Recombinant Anti-SEMA4A Vesicular Antibody, EV Displayed (VS-0425-YC155) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to SEMA4A-expressed cells or tissues. The SEMA4A is a protein involved in various functions, including axon guidance and immune modulation, with mutations associated with retinal degenerative diseases.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human tonsil
Immunohistochemical staining of human tonsil shows strong membranous positivity in a subset of non-germinal center cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/69136/152135_A_4_8_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuropil Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/69136/152135_B_8_5.jpg
Normal Tissue
Figure 3 Kidney
Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/69136/152135_A_8_5.jpg
Normal Tissue
Figure 4 Testis
Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/69136/152135_A_4_6.jpg
Normal Tissue
Figure 5 Lymph node
Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/69136/152135_A_8_8.jpg
Normal Tissue
Figure 6 Tonsil
Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/69136/152135_A_4_8.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (Karpas-707, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000196189-SEMA4A
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Recombinant Antibody
- Application
- Block, ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- SEMA4A
- Host Animal
- Mouse
- Antibody Isotype
- IgG2a
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Semaphorin 4A
- Biological Process
- Adaptive immunity, Angiogenesis, Differentiation, Immunity, Neurogenesis
- Molecular Function
- Developmental protein
- Introduction
- This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
- Alternative Names
- CORD10, FLJ12287, SEMAB, SemB
- Gene ID
- 64218
- UniProt ID
- Q9H3S1
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Datasheet
MSDS
COA
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See other products for "SEMA4A"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-422CT | Anti-Human SEMA4A Recombinant Antibody (HuLB51) | WB, ELISA, FC | Humanized antibody |
| TAB-423CT | Anti-Human SEMA4A Recombinant Antibody (HuLB70) | WB, ELISA, FC | Humanized antibody |
| TAB-422CT-S(P) | Anti-Human SEMA4A Recombinant Antibody scFv Fragment (HuLB51) | WB, ELISA, FC | Humanized antibody |
| TAB-423CT-S(P) | Anti-Human SEMA4A Recombinant Antibody scFv Fragment (HuLB70) | WB, ELISA, FC | Humanized antibody |
| TAB-422CT-F(E) | Anti-Human SEMA4A Recombinant Antibody Fab Fragment (HuLB51) | WB, ELISA, FC | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-424CT-S(P) | Anti-Human SEMA4A Recombinant Antibody scFv Fragment (126-28-1) | ELISA, FC, IHC, BL | |
| TAB-425CT-S(P) | Anti-Human SEMA4A Recombinant Antibody scFv Fragment (161-51-1) | ELISA, FC, BL | |
| TAB-426CT-S(P) | Anti-Human SEMA4A Recombinant Antibody scFv Fragment (161-70-1 ) | ELISA, FC, IHC, BL | |
| TAB-427CT-S(P) | Anti-Human SEMA4A Recombinant Antibody scFv Fragment (161-15B-1) | ELISA, FC, BL | |
| TAB-428CT-S(P) | Anti-Human SEMA4A Recombinant Antibody scFv Fragment (161-90) | ELISA, FC, BL |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1941CQ | Recombinant Rat Anti-Sema4a Antibody (CBL203) | FC, Neut | IgG1 |
| NEUT-1942CQ | Recombinant Rat Anti-Sema4a Antibody (CBL647) | FC, CyTOF, Neut | IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1282 | AbPlus™ Anti-SEMA4A Magnetic Beads (VS-0724-YC1282) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6443 | Anti-SEMA4A Immunohistochemistry Kit | IHC |
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