Recombinant Anti-SIGLEC10 Vesicular Antibody, EV Displayed (VS-0425-YC594)
CAT#: VS-0425-YC594
The Recombinant Anti-SIGLEC10 Vesicular Antibody, EV Displayed (VS-0425-YC594) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to SIGLEC10-expressed cells or tissues. SIGLEC10 belongs to the immunoglobulin superfamily, expressed on innate immune cells with inhibitory motifs. SIGLEC6, expressed on B-cells, is an exception within the SIGLEC family.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27093/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane, cytosol & actin filaments.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25807/if_selected.jpg
Normal Tissue
Figure 3 IHC staining of human bone marrow
Immunohistochemical staining of human bone marrow shows strong cytoplasmic positivity in subsets of cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27093/ihc_selected.jpg
Normal Tissue
Figure 4 Appendix
High expression in appendix
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25807/57426_A_1_2_val_selected.jpg
Normal Tissue
Figure 5 Lymph node
Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25807/57426_A_9_8.jpg
Normal Tissue
Figure 6 Cerebral cortex
Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25807/57426_B_9_5.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (Daudi, HDLM-2, HEL, HMC-1, NB-4, U-698, U-937)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000142512-SIGLEC10
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- SIGLEC10
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Sialic acid binding Ig like lectin 10
- Biological Process
- Adaptive immunity, Cell adhesion, Immunity, Innate immunity
- Cellular Localization
- Cytosol, Plasma membrane, Actin filaments
- Introduction
- SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).
- Alternative Names
- MGC126774, PRO940, SIGLEC-10, SLG2
- Gene ID
- 89790
- UniProt ID
- Q96LC7
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Datasheet
MSDS
COA
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See other products for "SIGLEC10"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0260-WJ | Mouse Anti-SIGLEC10 Recombinant Antibody (HPAB-0260-WJ) | ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0261-WJ | Mouse Anti-SIGLEC10 Recombinant Antibody (HPAB-0261-WJ) | ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0262-WJ | Mouse Anti-SIGLEC10 Recombinant Antibody (HPAB-0262-WJ) | ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0260-WJ-S(P) | Mouse Anti-SIGLEC10 Recombinant Antibody; scFv Fragment (HPAB-0260-WJ-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0261-WJ-S(P) | Mouse Anti-SIGLEC10 Recombinant Antibody; scFv Fragment (HPAB-0261-WJ-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0262-WJ-S(P) | Mouse Anti-SIGLEC10 Recombinant Antibody; scFv Fragment (HPAB-0262-WJ-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0260-WJ-F(E) | Mouse Anti-SIGLEC10 Recombinant Antibody; Fab Fragment (HPAB-0260-WJ-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0261-WJ-F(E) | Mouse Anti-SIGLEC10 Recombinant Antibody; Fab Fragment (HPAB-0261-WJ-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0262-WJ-F(E) | Mouse Anti-SIGLEC10 Recombinant Antibody; Fab Fragment (HPAB-0262-WJ-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6579 | Anti-SIGLEC10 Immunohistochemistry Kit | IHC |
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