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SIGLEC10
SIGLEC10 (Sialic Acid Binding Ig Like Lectin 10) is a Protein Coding gene. Diseases associated with SIGLEC10 include Stargardt Disease. Among its related pathways are Class I MHC mediated antigen processing and presentation and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is SIGLEC11.
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Kupffer cells, Macrophages, granulocytes, B-cells)
Immune cell specificity
Group enriched (eosinophil, non-classical monocyte, intermediate monocyte)
Cell line specificity
Cell line enhanced (Daudi, HDLM-2, HEL, HMC-1, NB-4, U-698, U-937)
Interaction
Interacts with PTPN6/SHP-1 upon phosphorylation (PubMed:12163025). Interacts with NCF1 (By similarity). Interacts with CD24; the probable CD24:SIGLEC10 complex is proposed to inhibit HGMB1-mediated tissue damage immune response. Interacts with HMGB1; the interaction is dependent on CD24 (PubMed:19264983). Interacts with DDX58, CBL and PTPN11 (By similarity).
More Types Infomation
- Mouse Anti-SIGLEC10 Recombinant Antibody; scFv Fragment (HPAB-0262-WJ-S(P)) (HPAB-0262-WJ-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
- Mouse Anti-SIGLEC10 Recombinant Antibody; scFv Fragment (HPAB-0261-WJ-S(P)) (HPAB-0261-WJ-S(P))
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
- Mouse Anti-SIGLEC10 Recombinant Antibody; scFv Fragment (HPAB-0260-WJ-S(P)) (HPAB-0260-WJ-S(P))
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
- Mouse Anti-SIGLEC10 Recombinant Antibody; Fab Fragment (HPAB-0262-WJ-F(E)) (HPAB-0262-WJ-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
- Mouse Anti-SIGLEC10 Recombinant Antibody; Fab Fragment (HPAB-0261-WJ-F(E)) (HPAB-0261-WJ-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
- Mouse Anti-SIGLEC10 Recombinant Antibody; Fab Fragment (HPAB-0260-WJ-F(E)) (HPAB-0260-WJ-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
- Mouse Anti-SIGLEC10 Recombinant Antibody (HPAB-0262-WJ) (HPAB-0262-WJ)
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA
- Mouse Anti-SIGLEC10 Recombinant Antibody (HPAB-0261-WJ) (HPAB-0261-WJ)
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA
- Mouse Anti-SIGLEC10 Recombinant Antibody (HPAB-0260-WJ) (HPAB-0260-WJ)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA
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For Research Use Only. Not For Clinical Use.