Recombinant Anti-SLC6A3 Vesicular Antibody, EV Displayed (VS-0425-YC752)
CAT#: VS-0425-YC752
The Recombinant Anti-SLC6A3 Vesicular Antibody, EV Displayed (VS-0425-YC752) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to SLC6A3-expressed cells or tissues. SLC6A3 is a dopamine transporter with a tandem repeat in the 3' UTR, linked to neurological disorders like ADHD and substance dependencies.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/13602/if_selected.jpg
Normal Tissue
Figure 2 Low expression in rectum.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78172/164529_A_4_3_val_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuropil Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78172/164529_B_8_5.jpg
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- SLC6A3
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Solute carrier family 6 member 3
- Biological Process
- Neurotransmitter transport, Symport, Transport
- Cellular Localization
- Vesicles
- Introduction
- This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.[provided by RefSeq, Nov 2009]
- Alternative Names
- DAT, DAT1
- Gene ID
- 6531
- UniProt ID
- Q01959
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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| MOR-3309 | Hi-Affi™ Recombinant Rabbit Anti-SLC6A3 Monoclonal Antibody (DS3309AB) | WB, IP, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0081-YC-S(P) | Mouse Anti-SLC6A3 Recombinant Antibody (clone K2-3f); scFv Fragment | ELISA, IF, WB | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0081-YC-F(E) | Mouse Anti-SLC6A3 Recombinant Antibody (clone K2-3f); Fab Fragment | ELISA, IF, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6692 | Anti-SLC6A3 Immunohistochemistry Kit | IHC |
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