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SLC6A3
Enables several functions, including amine binding activity; dopamine:sodium symporter activity; and enzyme binding activity. Involved in several processes, including dopamine transport; response to cAMP; and response to ethanol. Located in neuron projection and plasma membrane. Is active in dopaminergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Biomarker of Parkinsonism; heroin dependence; high grade glioma; hyperprolactinemia; and hypertension. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; nicotine dependence; and obesity.
Protein class
Disease related genes, FDA approved drug targets, Metabolic proteins, Transporters
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Alveolar cells type 2, Smooth muscle cells, Cardiomyocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Not detected
Interaction
Homooligomer; disulfide-linked (Ref. 14). Interacts with PRKCABP and TGFB1I1 (PubMed:11343649, PubMed:12177201). Interacts (via N-terminus) with SYNGR3 (via N-terminus) (By similarity). Interacts with SLC18A2 (By similarity). Interacts with TOR1A (ATP-bound); TOR1A regulates SLC6A3 subcellular location (PubMed:15505207). Interacts with alpha-synuclein/SNCA (PubMed:26442590). Interacts with SEPTIN4 (By similarity).
More Types Infomation
- Mouse Anti-SLC6A3 Recombinant Antibody (clone K2-3f); scFv Fragment (FAMAB-0081-YC-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, IF, WB
- Mouse Anti-SLC6A3 Recombinant Antibody (clone K2-3f); Fab Fragment (FAMAB-0081-YC-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, IF, WB
- Mouse Anti-SLC6A3 Antibody (clone K2-3f), mRNA (FAMAB-0081YC-mRNA)
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- Species Reactivity: Human
- Mouse Anti-SLC6A3 Recombinant Antibody (clone K2-3f) (FAMAB-0081YC)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, IF, WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, IHC
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, IP, FC
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- Species Reactivity: Mouse, Rat. Does not react with Human
- Type: Mouse IgG1
- Application: WB, IHC-P
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- Species Reactivity: Mouse, Rat. Does not react with Human
- Type: Mouse IgG1
- Application: IF, WB
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For Research Use Only. Not For Clinical Use.