Recombinant Mouse Anti-STMN1 Antibody (clone 10D6-2D10-2F9) (CAT#: VS3-FY1409)

• Immunogen
• Synthetic Peptides Derived from Human Stathmin.

• Host Species
• Mouse

• Type
• Mouse IgG2b

• Specificity
• Human STMN1

• Species Reactivity
• Human

• Clone
• 10D6-2D10-2F9

• Applications
• Immunohistochemistry-Paraffin

• Conjugate
• Unconjugated

• Purification
• Affinity Chromatography

• Purity
• >95% as determined by SDS-PAGE

• Buffer
• PBS, pH 7.3, 50% glycerol, 0.5% BSA

• Preservative
• 0.02% Sodium azide

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Immunohistochemistry-Paraffin: 1/100-1/500

• Alternative Names
• STMN1; C1orf215; LAP18; OP18; Stathmin; Leukemia-associated phosphoprotein p18; Metablastin; Oncoprotein 18; Op18; Phosphoprotein p19; pp19; Prosolin; Protein Pr22; pp17

• Gene ID
• 3925

• UniProt ID
• P16949

• Sequence Similarities
• Belongs to the stathmin family.

• Cellular Localization
• Cytoplasm, Cytoskeleton, Microtubule

• Post Translation Modifications
• Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization (By similarity).
  Phosphorylation at Ser-63 reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity.

• Protein Refseq
• NP_001138926.1; NP_005554.1; NP_981944.1

• Function
• Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity).

Secondary Antibody

• 2ND-049CQ
• Goat Anti-Mouse IgG2b Antibody, R-PE

• 2RD-A1466-YJ
• Goat Anti-Mouse IgG2b Secondary antibody

• 2RD-A1560-YJ
• Rabbit Anti-Mouse IgG2b Secondary antibody (Clone RM108)

Isotype Control

• MOB-203CQ
• Mouse IgG2b, kappa Isotype Control Antibody

• MOB-212YJL
• Mouse IgG2b kappa Isotype Control Antibody (Mopc21)

• MRO-A1611-YJ
• Mouse IgG2b Lambda Isotype control (M2BL)

Reconstitution Buffer

• MRO-0253YJ
• Reconstitution Buffer PBS

Recommended Dilution Buffer

• MRO-0253YJ
• Reconstitution Buffer PBS

Select a product category from the dropdown menu below to view related products.