Recombinant Mouse Anti-STMN1 Antibody (clone 10D6-2D10-2F9)
CAT#: VS3-FY1409
This product is a recombinant mouse antibody that recognizes STMN1. This antibody has been reported for use in Immunohistochemistry-Paraffin. The clone 10D6-2D10-2F9 is specific for human STMN1. The antigen is synthetic peptides derived from human stathmin.
Tested Data
Gene Expression
IHC-P
Figure 1. Recombinant Mouse Anti-STMN1 Antibody (clone 10D6-2D10-2F9) in IHC-P.
Immunohistochemical analysis of paraffin-embedded human Hodgkin.
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Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10107/if_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Glial cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous nuclear
Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68438/168896_B_8_5.jpg
Normal Tissue
Figure 3 Colon
Goblet cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Peripheral nerve/ganglion
Staining: High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68438/168896_A_8_3.jpg
Normal Tissue
Figure 4 Kidney
Collecting ducts
Staining: Medium
Intensity: Strong
Quantity: <25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68438/168896_A_7_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Leydig cells
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68438/168896_A_6_6.jpg
Normal Tissue
Figure 6 Lymph node
Germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68438/168896_A_7_8.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (MOLT-4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000117632-STMN1/subcellular
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Specifications
- Immunogen
- Synthetic Peptides Derived from Human Stathmin.
- Host Species
- Mouse
- Type
- Mouse IgG2b
- Specificity
- Human STMN1
- Species Reactivity
- Human
- Clone
- 10D6-2D10-2F9
- Applications
- Immunohistochemistry-Paraffin
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity Chromatography
- Purity
- >95% as determined by SDS-PAGE
- Buffer
- PBS, pH 7.3, 50% glycerol, 0.5% BSA
- Preservative
- 0.02% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Immunohistochemistry-Paraffin: 1/100-1/500
Target
- Alternative Names
- STMN1; C1orf215; LAP18; OP18; Stathmin; Leukemia-associated phosphoprotein p18; Metablastin; Oncoprotein 18; Op18; Phosphoprotein p19; pp19; Prosolin; Protein Pr22; pp17
- Gene ID
- 3925
- UniProt ID
- P16949
- Sequence Similarities
- Belongs to the stathmin family.
- Cellular Localization
- Cytoplasm, Cytoskeleton, Microtubule
- Post Translation Modifications
- Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization (By similarity).
Phosphorylation at Ser-63 reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity.
- Protein Refseq
- NP_001138926.1; NP_005554.1; NP_981944.1
- Function
- Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3537z | Mouse Anti-STMN1 Recombinant Antibody (clone 11H12) | WB, FC, ICC, IF, IHC | Mouse IgG2b |
| MOB-1958CT | Recombinant Mouse anti-Human STMN1 Monoclonal antibody (24) | ELISA, WB | |
| MRO-1445-CN | Recombinant Rabbit Anti-STMN1 Monoclonal Antibody (SS0453) | WB, IF, IHC, IP, FC | Rabbit IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3443 | Hi-Affi™ Recombinant Rabbit Anti-STMN1 Monoclonal Antibody (DS3443AB) | IHC-P, IP, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC1122 | CytoStream™ Rabbit Anti-STMN1 Recombinant Antibody (VS13-YC1122) | WB, ICC, IF, IHC-P, FC, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2212 | Anti-STMN1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY6991 | Anti-Human STMN1 Immunohistochemistry Kit | IHC |
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