Recombinant Anti-STXBP1 Vesicular Antibody, EV Displayed (VS-0425-YC63)
CAT#: VS-0425-YC63
The Recombinant Anti-STXBP1 Vesicular Antibody, EV Displayed (VS-0425-YC63) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to STXBP1-expressed cells or tissues. The STXBP1 protein is crucial for synaptic vesicle priming, impacting synaptic transmission and associated with conditions like West syndrome.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line SK-MEL-30
Immunofluorescent staining of human cell line SK-MEL-30 shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8209/if_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enhanced (SCLC-21H, SK-MEL-30)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000136854-STXBP1/subcellular
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- STXBP1
- Host Animal
- Rabbit
- Antibody Isotype
- IgG
- Species Reactivity
- Rat, Mouse
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Syntaxin binding protein 1
- Biological Process
- Protein transport, Transport
- Cellular Localization
- Nucleoplasm, Cytosol
- Introduction
- Enables syntaxin-1 binding activity. Involved in synaptic vesicle priming and vesicle docking involved in exocytosis. Acts upstream of or within several processes, including axon target recognition; chemical synaptic transmission; and negative regulation of synaptic transmission. Located in axon; phagocytic vesicle; and plasma membrane. Is active in several cellular components, including parallel fiber to Purkinje cell synapse; presynaptic active zone cytoplasmic component; and presynaptic cytosol. Is extrinsic component of presynaptic membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and sensory organ. Human ortholog(s) of this gene implicated in West syndrome and developmental and epileptic encephalopathy 4.
- Alternative Names
- Ms10g; nsec1; N-sec1; Sxtbp1; Unc18h; MMS10-G; Rb-sec1; Unc18-1; Munc-18a; Munc18-1
- Gene ID
- 20910
- UniProt ID
- O08599
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| VS-0325-XY2222 | Anti-STXBP1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7009 | Anti-Mouse STXBP1 Immunohistochemistry Kit | IHC | |
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