Rabbit Anti-STXBP1 Recombinant Antibody (clone R05-4B6)
CAT#: VS3-FY2041
The R05-4B6 recombinant monoclonal antibody has a high affinity for human STXBP1. It cross-reacts with mouse, rat. This syntaxin binding protein 1 antibody has been rigorously validated and is widely used in western blot analysis of Munc181 in mouse brain lysates.
Gene Expression
Tested Data
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line SK-MEL-30
Immunofluorescent staining of human cell line SK-MEL-30 shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8209/if_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enhanced (SCLC-21H, SK-MEL-30)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000136854-STXBP1/subcellular
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WB
Figure 1 Anti-STXBP1 Antibody (VS3-FY2041) in WB.
The Munc181 expression in mouse brain lysates were detected using the anti-Syntaxin Binding Protein 1 by western blot assay.
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Specifications
- Immunogen
- Synthetic peptide of human Munc18-1
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat STXBP1
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R05-4B6
- Applications
- Western Blot
- MW
- The calculated weight of the target protein is approximately 68 kDa, while the observed molecular weight stands at 68 kDa.
- Related Disease
- Developmental And Epileptic Encephalopathy 4 and Infantile Epilepsy Syndrome
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% glycerol, 0.05% BSA
- Preservative
- 0.01% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Target
- Alternative Names
- P67; NSEC1; UNC18; RBSEC1; MUNC18-1
- Gene ID
- 6812
- UniProt ID
- P61764
- Sequence Similarities
- Belongs to the STXBP/unc-18/SEC1 family.
- Cellular Localization
- Cytoplasm, Membrane
- Post Translation Modifications
- Modification sites at PhosphoSitePlus (P61764)
Modification sites at neXtProt (NX_P61764)
Glycosylation from GlyGen (P61764) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- NP_001027392.1; NP_001361235.1; NP_001361236.1; NP_001361237.1; NP_001361238.1
- Function
- Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins (By similarity).
Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "STXBP1"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1164MZ | Recombinant Mouse Anti-Human STXBP1 Antibody | IHC-P, WB | Mouse antibody |
| VS-0223-WK48 | Rabbit Anti-STXBP1 Recombinant Antibody (VS-0223-WK48) | WB, ICC | Rabbit IgG |
| VS13-YC1126 | Rabbit Anti-STXBP1 Recombinant Antibody (VS13-YC1126) | WB, IHC-P, ICC, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3453 | Hi-Affi™ Recombinant Rabbit Anti-STXBP1 Monoclonal Antibody (DS3453AB) | WB, IP, ICC, IF | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2222 | Anti-STXBP1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7009 | Anti-Mouse STXBP1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7008 | Anti-Human STXBP1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC63 | Recombinant Anti-STXBP1 Vesicular Antibody, EV Displayed (VS-0425-YC63) | ELISA, FC, Cell-uptake |
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