Recombinant Anti-THPO Vesicular Antibody, EV Displayed (VS-0425-YC388)
CAT#: VS-0425-YC388
The Recombinant Anti-THPO Vesicular Antibody, EV Displayed (VS-0425-YC388) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to THPO-expressed cells or tissues. The THPO is a growth factor essential for megakaryocyte maturation and platelet production, with mutations causing thrombocythemia.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (CACO-2, Hep G2, K-562, RPMI-8226)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000090534-THPO/subcellular
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Recombinant Antibody
- Application
- ELISA, FC, Neut, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- THPO
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Thrombopoietin
- Molecular Function
- Cytokine, Hormone
- Introduction
- Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent. [provided by RefSeq, Feb 2014]
- Alternative Names
- MGDF, MPLLG, TPO
- Gene ID
- 7066
- UniProt ID
- P40225
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-973-F(E) | Recombinant Anti-human THPO Antibody Fab Fragment | IF, FC, FuncS | Fab |
| MHH-973-F(E) | Recombinant Human Anti-human THPO Antibody Fab Fragment | ELISA, WB, FuncS | Fab |
| PFBZ-075 | Mouse Anti-THPO Recombinant Antibody (clone TN1); Fab Fragment | Neut, ELISA | Mouse Fab |
| PFBW-122 | Human Anti-THPO Recombinant Antibody (clone TN1); Fab Fragment | Neut | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-973-S(P) | Recombinant Anti-human THPO Antibody scFv Fragment | ELISA, WB, FC, FuncS | scFv |
| MHH-973-S(P) | Recombinant Human Anti-human THPO Antibody scFv Fragment | ELISA, WB, IP, FuncS | scFv |
| PSBZ-075 | Mouse Anti-THPO Recombinant Antibody (clone TN1); scFv Fragment | Neut, ELISA | Mouse scFv |
| PSBW-122 | Human Anti-THPO Recombinant Antibody (clone TN1); scFv Fragment | Neut | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-973 | Recombinant Human Anti-human THPO Antibody | ELISA, IP, FuncS | IgG |
| MOB-0207MC | Anti-Dog (Canine) Thrombopoietin Antibody | WB | |
| MOB-0208MC | Mouse Anti-THPO Recombinant Antibody (clone YC167) | WB, ICC, IHC-P, IHC-F, ELISA | Mouse IgG |
| PABZ-075 | Mouse Anti-THPO Recombinant Antibody (clone TN1) | Neut, ELISA | Mouse IgG |
| VS3-XY1514 | Mouse Anti-THPO Recombinant Antibody (clone 1B11) | ELISA, WB, FC | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-178 | Recombinant Mouse Anti-Thrombopoietin Antibody (TN1) | WB, Neut, FuncS | IgG |
| PABX-178-S (P) | Recombinant Mouse Anti-Thrombopoietin Antibody scFv Fragment (TN1) | WB, Neut, FuncS | scFv |
| PABX-178-F (E) | Recombinant Mouse Anti-Thrombopoietin Antibody Fab Fragment (TN1 ) | WB, Neut, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3566 | Rabbit Anti-Thpo Recombinant Antibody (clone DS3566AB) | ELISA | Rabbit IgG |
| MOR-4456 | Rabbit Anti-THPO Recombinant Antibody (clone SI549DS) | ELISA | Rabbit IgG |
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