Recombinant Mouse Anti-Thrombopoietin Antibody Fab Fragment (TN1 ) (CAT#: PABX-178-F (E))
Anti-Thrombopoietin antibody is a Mouse of Fab class that binds to an Thrombopoietin.
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Figure 1 Results of TN1-Fab–hTPO163 binding measured using ITC.
(A) Titration calorimetry signals of TN1-Fab–hTPO163 binding reaction (lower line) with corresponding blank titration (upper line) at 298 K. (B) Integrated heat profile of the calorimetric titration at 298 K. Solid circles are integrated data. Solid line is a best-fit using a 1:1 binding model. (C) Temperature dependence plot of ∆Hobs, ∆G0, and -T∆S0. ∆G0 and -T∆S0 values were calculated using Equations (1) and (2). (D) –R ln Ka versus 1 / T plot. A linear least square fitting (dash line) by Equation (3) yields a slope of 24.4 kJ mol-1.
Arai, S., Shibazaki, C., Adachi, M., Honjo, E., Tamada, T., Maeda, Y., ... & Kuroki, R. (2016). An insight into the thermodynamic characteristics of human thrombopoietin complexation with TN1 antibody. Protein Science, 25(10), 1786-1796.
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Figure 2 The overall structure of TN1-Fab.
(A) and (B) show the free TN1-Fab (PDB ID: 2ZKH, this work) and TN1-Fab–hTPO163 complex (PDB ID: 1V7M), respectively. For free TN1-Fab, the heavy and light chains are represented by red and yellow, respectively. For the TN1-Fab–hTPO163 complex, the heavy and light chains of TN1-Fab are represented by blue and green, respectively, and hTPO163 is depicted in gray. The dotted lines show the two pseudo-dyad axes generated by the superposition of CL on to CH1, and of VL on to VH.
Arai, S., Shibazaki, C., Adachi, M., Honjo, E., Tamada, T., Maeda, Y., ... & Kuroki, R. (2016). An insight into the thermodynamic characteristics of human thrombopoietin complexation with TN1 antibody. Protein Science, 25(10), 1786-1796.
Specifications
- Immunogen
- Recombinant hTPO (28)
- Host Species
- Mouse
- Derivation
- Mouse
- Type
- Fab
- Specificity
- Tested positive against native Human Thrombopoietin
- Species Reactivity
- Human
- Clone
- TN1
- Applications
- WB 1:1000-1:5000
Neut (assay dependent)
FuncS (assay dependent)
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- Assay-depended
Target
- Alternative Names
- THPO; thrombopoietin; ML; TPO; MGDF; MKCSF; MPLLG; THCYT1; MPL ligand; c-mpl ligand; megakaryocyte colony-stimulating factor; megakaryocyte growth and development factor; megakaryocyte stimulating factor; myeloproliferative leukemia virus oncogene ligand; prepro-thrombopoietin
- Gene ID
- 7066
- UniProt ID
- P40225
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-973 | Recombinant Anti-human THPO Antibody | WB, IF, FuncS | IgG |
| MOB-0207MC | Anti-Dog (Canine) Thrombopoietin Antibody | WB | |
| MOB-0208MC | Mouse Anti-THPO Recombinant Antibody (clone YC167) | WB, ICC, IHC-P, IHC-F, ELISA | Mouse IgG |
| PABW-122 | Human Anti-THPO Recombinant Antibody (clone TN1) | Neut | Human IgG |
| VS3-XY1514 | Mouse Anti-THPO Recombinant Antibody (clone 1B11) | ELISA, WB, FC | Mouse IgG2a |
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