Recombinant Anti-TNFRSF13C Vesicular Antibody, EV Displayed (VS-0425-YC545)
CAT#: VS-0425-YC545
The Recombinant Anti-TNFRSF13C Vesicular Antibody, EV Displayed (VS-0425-YC545) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to TNFRSF13C-expressed cells or tissues. TNFRSF13C is a BAFF receptor, crucial for B-cell survival. Abnormally high BAFF levels may contribute to autoimmune diseases like systemic lupus erythematosus.
Gene Expression
Normal Tissue
Figure 1 Colon
Mucosal lymphoid cells
Staining:Medium
Intensity: Strong
Quantity: <25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8380/19871_A_7_3.jpg
Normal Tissue
Figure 2 Lymph node
Germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8380/19871_A_9_8.jpg
RNA Expression
Figure 3 RNA cell line category: Group enriched (REH, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000159958-TNFRSF13C
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Recombinant Antibody
- Application
- ELISA, FC, Neut, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- TNFRSF13C
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human, Cynomolgus
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- TNF receptor superfamily member 13C
- Biological Process
- Adaptive immunity, Immunity
- Molecular Function
- Receptor
- Introduction
- B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival.
- Alternative Names
- BAFFR, CD268
- Gene ID
- 115650
- UniProt ID
- Q96RJ3
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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| PFBW-087 | Human Anti-Tnfrsf13c Recombinant Antibody (clone CB2); Fab Fragment | ELISA | Human Fab |
| PFBZ-123 | Human Anti-TNFRSF13C Recombinant Antibody (clone CB3s); Fab Fragment | ELISA | Human Fab |
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| PSBZ-123 | Human Anti-TNFRSF13C Recombinant Antibody (clone CB3s); scFv Fragment | ELISA | Human scFv |
| HPAB-0741-CN-S(P) | Human Anti-TNFRSF13C Recombinant Antibody; scFv Fragment (HPAB-0741-CN-S(P)) | ELISA, FC, Neut | Human scFv |
| HPAB-AP472-YC-S(P) | Human Anti-TNFRSF13C Recombinant Antibody; scFv Fragment (HPAB-AP472-YC-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| TAB-1199CL | Mouse Anti-TNFRSF13C Recombinant Antibody (TAB-1199CL) | Block, FuncS | Mouse IgG |
| TAB-1200CL | Mouse Anti-TNFRSF13C Recombinant Antibody (TAB-1200CL) | Block, FuncS | Mouse IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| TAB-1203CL-F(E) | Human Anti-TNFRSF13C Recombinant Antibody; Fab Fragment (TAB-1203CL-F(E)) | ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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