Recombinant Anti-TNFRSF21 Vesicular Antibody, EV Displayed (VS-0425-YC107)
CAT#: VS-0425-YC107
The Recombinant Anti-TNFRSF21 Vesicular Antibody, EV Displayed (VS-0425-YC107) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to TNFRSF21-expressed cells or tissues. The TNFRSF21 is a receptor involved in cell apoptosis regulation and immune function, linked to T-helper cell activation.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9805/931_E7_1_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human cerebral cortex
Immunohistochemical staining of human cerebral cortex shows strong cytoplasmic positivity in neuronal cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6746/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
Glial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6746/22058_B_7_5.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6746/22058_A_9_3.jpg
Normal Tissue
Figure 5 Liver
Cholangiocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6746/22058_A_8_4.jpg
Normal Tissue
Figure 6 Pancreas
Exocrine glandular cells
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
Pancreatic endocrine cells
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6746/22058_A_1_3.jpg
Normal Tissue
Figure 7 Kidney
Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6746/22058_A_9_5.jpg
Normal Tissue
Figure 8 Testis
Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6746/22058_A_5_6.jpg
Normal Tissue
Figure 9 Lymph node
Germinal center cells
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6746/22058_A_8_8.jpg
RNA Expression
Figure 10 RNA cell line category: Cell line enhanced (OE19, RT4, SuSa)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000146072-TNFRSF21/subcellular
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Stim, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- TNFRSF21
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- TNF receptor superfamily member 21
- Biological Process
- Adaptive immunity, Apoptosis, Host-virus interaction, Immunity
- Molecular Function
- Receptor
- Cellular Localization
- Plasma membrane, Cytosol
- Introduction
- This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation.
- Alternative Names
- CD358, DR6
- Gene ID
- 27242
- UniProt ID
- O75509
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-984 | Recombinant Anti-human TNFRSF21 Antibody | ELISA, WB, FuncS | IgG |
| MHH-984 | Recombinant Human Anti-human TNFRSF21 Antibody | IF, FC, FuncS | IgG |
| MOB-2092MZ | Recombinant Mouse Anti-Human TNFRSF21 Antibody (clone ES-7-05-FD) | FC, ICC, IF, IP | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-984-F(E) | Recombinant Anti-human TNFRSF21 Antibody Fab Fragment | RIA, IP, FuncS | Fab |
| MHH-984-F(E) | Recombinant Human Anti-human TNFRSF21 Antibody Fab Fragment | WB, IF, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-984-S(P) | Recombinant Anti-human TNFRSF21 Antibody scFv Fragment | ELISA, IP, FuncS | scFv |
| MHH-984-S(P) | Recombinant Human Anti-human TNFRSF21 Antibody scFv Fragment | WB, Neut, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-631CL | Anti-Human TNFRSF21 Recombinant Antibody (DQM3) | Stim | Antibody |
| CAT | Product Name | Application | Type |
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| TAB-108CQ-S(P) | Mouse Anti-TNFRSF21 Recombinant Antibody; scFv Fragment (TAB-108CQ-S(P)) | ELISA, FC, IHC, WB, IP | Mouse scFv |
| TAB-108CQ-F(E) | Mouse Anti-TNFRSF21 Recombinant Antibody; Fab Fragment (TAB-108CQ-F(E)) | ELISA, FC, IHC, WB, IP | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-109CQ-S(P) | Human Anti-TNFRSF21 Recombinant Antibody; scFv Fragment (TAB-109CQ-S(P)) | ELISA, FC, IHC, WB, IP | Human scFv |
| TAB-109CQ-F(E) | Human Anti-TNFRSF21 Recombinant Antibody; Fab Fragment (TAB-109CQ-F(E)) | ELISA, FC, IHC, WB, IP | Human Fab |
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