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TNFRSF21

DQM3 is a functional agonist monoclonal antibody against DR6, which bound to the first cysteine-rich domain. Death receptor 6 (DR6) is a member of the death domain-containing receptors that belong to the TNFR superfamily.
Protein class

CD markers, Metabolic proteins, Plasma proteins

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Urothelial cells, Prostatic glandular cells, Basal prostatic cells, Syncytiotrophoblasts)

Immune cell specificity

Immune cell enriched (plasmacytoid DC)

Cell line specificity

Cell line enhanced (OE19, RT4, SuSa)

Interaction

Interacts with N-APP (By similarity). Associates with TRADD. Interacts with NGFR. (Microbial infection) Interacts with hepatitis C virus (HCV) non-structural protein 5A; this interaction allows the modulation by the virus of JNK, p38 MAPK, STAT3, and Akt signaling pathways in a DR6-dependent manner.

Molecular function

Receptor

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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