Anti-Human TNFRSF21 Recombinant Antibody (DQM3)
CAT#: TAB-631CL
Recombinant Human monoclonal antibody expressed in CHO binding to Human TNFRSF21. DQM3 is a functional agonist monoclonal antibody against DR6, which bound to the first cysteine-rich domain. Death receptor 6 (DR6) is a member of the death domain-containing receptors that belong to the TNFR superfamily.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9805/931_E7_1_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human cerebral cortex
Immunohistochemical staining of human cerebral cortex shows strong cytoplasmic positivity in neuronal cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6746/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
Glial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6746/22058_B_7_5.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6746/22058_A_9_3.jpg
Normal Tissue
Figure 5 Liver
Cholangiocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6746/22058_A_8_4.jpg
Normal Tissue
Figure 6 Pancreas
Exocrine glandular cells
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
Pancreatic endocrine cells
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6746/22058_A_1_3.jpg
Normal Tissue
Figure 7 Kidney
Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6746/22058_A_9_5.jpg
Normal Tissue
Figure 8 Testis
Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6746/22058_A_5_6.jpg
Normal Tissue
Figure 9 Lymph node
Germinal center cells
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6746/22058_A_8_8.jpg
RNA Expression
Figure 10 RNA cell line category: Cell line enhanced (OE19, RT4, SuSa)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000146072-TNFRSF21/subcellular
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Specifications
- Host Species
- Human
- Type
- Antibody
- Species Reactivity
- Human
- Applications
- Stim
- Related Disease
- Cancer
Product Property
- Purity
- >95%, by SDS-PAGE with Coomassie Brilliant Blue staining
- Storage
- Short term: store at 4°C (over 6 months), long term: -20°C or -80°C.
Applications
- Application Notes
- This antibody has been tested for use in Stimulation. It's recommended that the optimal antibody concentration, dilution, incubition time, etc. be carefully titrated in specific assays.
Target
- Alternative Names
- TNFRSF21; tumor necrosis factor receptor superfamily, member 21; DR6; CD358; BM-018; tumor necrosis factor receptor superfamily member 21; death receptor 6; TNFR-related death receptor 6
- Gene ID
- 27242
- UniProt ID
- A0A024RD71
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "TNFRSF21"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-984 | Recombinant Anti-human TNFRSF21 Antibody | ELISA, WB, FuncS | IgG |
| MHH-984 | Recombinant Human Anti-human TNFRSF21 Antibody | IF, FC, FuncS | IgG |
| MOB-2092MZ | Recombinant Mouse Anti-Human TNFRSF21 Antibody (clone ES-7-05-FD) | FC, ICC, IF, IP | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-984-F(E) | Recombinant Anti-human TNFRSF21 Antibody Fab Fragment | RIA, IP, FuncS | Fab |
| MHH-984-F(E) | Recombinant Human Anti-human TNFRSF21 Antibody Fab Fragment | WB, IF, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-984-S(P) | Recombinant Anti-human TNFRSF21 Antibody scFv Fragment | ELISA, IP, FuncS | scFv |
| MHH-984-S(P) | Recombinant Human Anti-human TNFRSF21 Antibody scFv Fragment | WB, Neut, FuncS | scFv |
| CAT | Product Name | Application | Type |
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| TAB-108CQ-S(P) | Mouse Anti-TNFRSF21 Recombinant Antibody; scFv Fragment (TAB-108CQ-S(P)) | ELISA, FC, IHC, WB, IP | Mouse scFv |
| TAB-108CQ-F(E) | Mouse Anti-TNFRSF21 Recombinant Antibody; Fab Fragment (TAB-108CQ-F(E)) | ELISA, FC, IHC, WB, IP | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-109CQ-S(P) | Human Anti-TNFRSF21 Recombinant Antibody; scFv Fragment (TAB-109CQ-S(P)) | ELISA, FC, IHC, WB, IP | Human scFv |
| TAB-109CQ-F(E) | Human Anti-TNFRSF21 Recombinant Antibody; Fab Fragment (TAB-109CQ-F(E)) | ELISA, FC, IHC, WB, IP | Human Fab |
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| VS-0425-YC107 | Recombinant Anti-TNFRSF21 Vesicular Antibody, EV Displayed (VS-0425-YC107) | ELISA, FC, Stim, Cell-uptake |
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