Recombinant Anti-TNFRSF25 Vesicular Antibody, EV Displayed (VS-0425-YC198)
CAT#: VS-0425-YC198
The Recombinant Anti-TNFRSF25 Vesicular Antibody, EV Displayed (VS-0425-YC198) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to TNFRSF25-expressed cells or tissues. The TNFRSF25 is a receptor within the TNF-receptor superfamily, regulating lymphocyte homeostasis. It stimulates NF-kappa B activity, influencing apoptosis and lymphocyte responses. Alternative splicing generates different isoforms, impacting T-cell activation.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HaCaT
Immunofluorescent staining of human cell line HaCaT shows localization to nucleoplasm, plasma membrane & actin filaments.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69834/1324_B9_9_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enhanced (HDLM-2, RPMI-8226)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000215788-TNFRSF25
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Recombinant Antibody
- Application
- Block, ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- TNFRSF25
- Host Animal
- Human
- Antibody Isotype
- IgG
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- TNF receptor superfamily member 25
- Biological Process
- Apoptosis
- Molecular Function
- Receptor
- Cellular Localization
- Plasma membrane, Actin filaments, Focal adhesion sites, Nucleoplasm
- Introduction
- The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation.
- Alternative Names
- APO-3, DDR3, DR3, LARD, TNFRSF12, TR3, TRAMP, WSL-1, WSL-LR
- Gene ID
- 8718
- UniProt ID
- Q93038
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Datasheet
MSDS
COA
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| HPAB-0789YY-F(E) | Human Anti-TNFRSF25 Recombinant Antibody; Fab Fragment (HPAB-0789YY-F(E)) | ELISA | Humanized Fab |
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