This product is a recombinant Chimeric (Human/Mouse) antibody that recognizes human TNFRSF25. It displays a decreased agonistic activity or no agonistic activity for DR3.
Figure 1 indicate comparison of isotype effects on anti-DR3 antibody agonist activities.
The effects of indicated 142A2 IgG1, IgG2, and IgG4v versions on PBMCs NF-kB activation were determined. The longitudinal axis indicates p65 phosphorylation-positive cells (%) in PBMCs and the horizontal axis indicates added antibodies. TL1A was added at 40 nM concentration and each antibody was added at 6.67 nM concentration.
Figure 2 indicate comparison of isotype effects on anti-DR3 antibody antagonist activities.
The effects of indicated 142A2 IgG1, IgG2, and IgG4v versions on PBMCs NF-kB activation were determined. The longitudinal axis indicates p65 phosphorylation-positive cells (%) in PBMCs and the horizontal axis indicates added antibodies. TL1A was added at 40 nM concentration and each antibody was added at 6.67 nM concentration.
Figure 3 indicate an agonism on p65 phosphorylation level of anti-DR3 antibody IgG2, IgG4 variant, IgG4244 variant and IgG2422 variant.
The longitudinal axis indicates p65 phosphorylation-positive cells (%) in PBMCs and the horizontal axis indicates antibody concentration (nM).
Figure 4 indicate an antagonism on p65 phosphorylation level of anti-DR3 antibody IgG2, IgG4 variant, IgG4244 variant and IgG2422 variant.
The longitudinal axis indicates p65 phosphorylation-positive cells (%) in PBMCs and the horizontal axis indicates antibody concentration (μgmL). 55% and 1.8% of cells were phosphorylated-p65 positive following TL1A treatment alone or medium alone.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-242MZ | Mouse Anti-TNFRSF25 Recombinant Antibody (TAB-242MZ) | ELISA | Mouse lgG1 |
TAB-243MZ | Mouse Anti-TNFRSF25 Recombinant Antibody (TAB-243MZ) | ELISA | Mouse lgG1 |
TAB-244MZ | Mouse Anti-TNFRSF25 Recombinant Antibody (TAB-244MZ) | ELISA | Mouse IgG2a |
TAB-245MZ | Anti-Human TNFRSF25 Recombinant Antibody (11H08 ) | Agonist, Block, FC, FuncS | |
TAB-242MZ-S(P) | Mouse Anti-TNFRSF25 Recombinant Antibody; scFv Fragment (TAB-242MZ-S(P)) | ELISA | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-246MZ | Anti-Human TNFRSF25 Recombinant Antibody (11H08_H1) | Agonist, Block, FC, FuncS | Humanized antibody |
TAB-246MZ-S(P) | Anti-Human TNFRSF25 Recombinant Antibody scFv Fragment (11H08_H1) | FC | Humanized antibody |
TAB-246MZ-F(E) | Anti-Human TNFRSF25 Recombinant Antibody Fab Fragment (11H08_H1) | FC | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-2089MZ | Recombinant Mouse Anti-Human TNFRSF25 Antibody (clone 1H2) | WB | Mouse antibody |
HPAB-0722YY | Human Anti-TNFRSF25 Recombinant Antibody (HPAB-0722YY) | ELISA | Humanized IgG |
HPAB-0723YY | Human Anti-TNFRSF25 Recombinant Antibody (HPAB-0723YY) | ELISA | Humanized IgG |
HPAB-0788YY | Human Anti-TNFRSF25 Recombinant Antibody (HPAB-0788YY) | ELISA, FC, ADCC | Humanized IgG |
HPAB-0789YY | Human Anti-TNFRSF25 Recombinant Antibody (HPAB-0789YY) | ELISA, FC, ADCC | Humanized IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0333-YJ-S(P) | Mouse Anti-TNFRSF25 Recombinant Antibody (clone Ch142A2); scFv Fragment | FC, Antagonist | Mouse scFv |
HPAB-0722YY-S(P) | Human Anti-TNFRSF25 Recombinant Antibody; scFv Fragment (HPAB-0722YY-S(P)) | ELISA | Human scFv |
HPAB-0723YY-S(P) | Human Anti-TNFRSF25 Recombinant Antibody; scFv Fragment (HPAB-0723YY-S(P)) | ELISA | Human scFv |
HPAB-0788YY-S(P) | Human Anti-TNFRSF25 Recombinant Antibody; scFv Fragment (HPAB-0788YY-S(P)) | ELISA | Human scFv |
HPAB-0789YY-S(P) | Human Anti-TNFRSF25 Recombinant Antibody; scFv Fragment (HPAB-0789YY-S(P)) | ELISA | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0333-YJ-F(E) | Human Anti-TNFRSF25 Recombinant Antibody (clone Ch142A2); Fab Fragment | FC, Antagonist | Human Fab |
HPAB-0722YY-F(E) | Human Anti-TNFRSF25 Recombinant Antibody; Fab Fragment (HPAB-0722YY-F(E)) | ELISA | Humanized Fab |
HPAB-0723YY-F(E) | Human Anti-TNFRSF25 Recombinant Antibody; Fab Fragment (HPAB-0723YY-F(E)) | ELISA | Humanized Fab |
HPAB-0788YY-F(E) | Human Anti-TNFRSF25 Recombinant Antibody; Fab Fragment (HPAB-0788YY-F(E)) | ELISA | Humanized Fab |
HPAB-0789YY-F(E) | Human Anti-TNFRSF25 Recombinant Antibody; Fab Fragment (HPAB-0789YY-F(E)) | ELISA | Humanized Fab |
There are currently no Customer reviews or questions for HPAB-0333-YJ. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.