This antibody that specifically binds to DR3 receptors has uses in the prevention, detection, diagnosis, treatment or amelioration of a disease or disorder, especially inflammatory and autoimmune diseases, such as Crohn's disease, Inflammatory Bowel Disease, Multiple Sclerosis.
Figure 1 Flow cytometry results of 11H08 binding to hDR3-expressing HEK293F cells.
Figuge 2 Agonist activity of the whole 11H08 antibody.
TF1 cells were treated with media and cycloheximide along with varying concentrations of the whole 11H08 immunoglobulin or 10 ng/mL of the positive control hTL1A protein, as indicated. This was compared with cells treated only with media and cycloheximide. Full length anti-DR3 antibodies act as TL1A agonists and induce cell death.
Figure 3 11H08-Fab molecules block TL1A-induced cell death.
TF-1 cells were treated with 10 ng/mL hTL1A and cycloheximide, along with varying concentrations of the anti-DR3 Fab molecules H1L2-Fab, H5L2-Fab and 11H08-Fab, as indicated. As shown by the graph, H1L2-Fab, H5L2-Fab and 11H08-Fab inhibited TL1A-induced apoptosis in human TF-1 cells, showing a dose-dependent prevention of apoptosis in cycloheximide-treated TF-1 cells in the presence of TL1A.
Figure 4 Anti-DR3 Fab-HSA molecules block TL1A-induced cytokine release.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-242MZ-S(P) | Mouse Anti-TNFRSF25 Recombinant Antibody; scFv Fragment (TAB-242MZ-S(P)) | ELISA | Mouse scFv |
TAB-242MZ-F(E) | Mouse Anti-TNFRSF25 Recombinant Antibody; Fab Fragment (TAB-242MZ-F(E)) | ELISA | Mouse Fab |
TAB-243MZ-F(E) | Mouse Anti-TNFRSF25 Recombinant Antibody; Fab Fragment (TAB-243MZ-F(E)) | ELISA | Mouse Fab |
TAB-244MZ-F(E) | Mouse Anti-TNFRSF25 Recombinant Antibody; Fab Fragment (TAB-244MZ-F(E)) | ELISA | Mouse Fab |
TAB-245MZ-F(E) | Anti-Human TNFRSF25 Recombinant Antibody Fab Fragment (11H08 ) | FC |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-246MZ-S(P) | Anti-Human TNFRSF25 Recombinant Antibody scFv Fragment (11H08_H1) | FC | Humanized antibody |
TAB-246MZ-F(E) | Anti-Human TNFRSF25 Recombinant Antibody Fab Fragment (11H08_H1) | FC | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0333-YJ | Human Anti-TNFRSF25 Recombinant Antibody (clone Ch142A2) | FC, Antagonism, FuncS | Chimeric (mouse/human) IgG2, κ |
HPAB-0722YY | Human Anti-TNFRSF25 Recombinant Antibody (HPAB-0722YY) | ELISA | Humanized IgG |
HPAB-0723YY | Human Anti-TNFRSF25 Recombinant Antibody (HPAB-0723YY) | ELISA | Humanized IgG |
HPAB-0788YY | Human Anti-TNFRSF25 Recombinant Antibody (HPAB-0788YY) | ELISA, FC, ADCC | Humanized IgG |
HPAB-0789YY | Human Anti-TNFRSF25 Recombinant Antibody (HPAB-0789YY) | ELISA, FC, ADCC | Humanized IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0333-YJ-S(P) | Mouse Anti-TNFRSF25 Recombinant Antibody (clone Ch142A2); scFv Fragment | FC, Antagonist | Mouse scFv |
HPAB-0722YY-S(P) | Human Anti-TNFRSF25 Recombinant Antibody; scFv Fragment (HPAB-0722YY-S(P)) | ELISA | Human scFv |
HPAB-0723YY-S(P) | Human Anti-TNFRSF25 Recombinant Antibody; scFv Fragment (HPAB-0723YY-S(P)) | ELISA | Human scFv |
HPAB-0788YY-S(P) | Human Anti-TNFRSF25 Recombinant Antibody; scFv Fragment (HPAB-0788YY-S(P)) | ELISA | Human scFv |
HPAB-0789YY-S(P) | Human Anti-TNFRSF25 Recombinant Antibody; scFv Fragment (HPAB-0789YY-S(P)) | ELISA | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0333-YJ-F(E) | Human Anti-TNFRSF25 Recombinant Antibody (clone Ch142A2); Fab Fragment | FC, Antagonist | Human Fab |
HPAB-0722YY-F(E) | Human Anti-TNFRSF25 Recombinant Antibody; Fab Fragment (HPAB-0722YY-F(E)) | ELISA | Humanized Fab |
HPAB-0723YY-F(E) | Human Anti-TNFRSF25 Recombinant Antibody; Fab Fragment (HPAB-0723YY-F(E)) | ELISA | Humanized Fab |
HPAB-0788YY-F(E) | Human Anti-TNFRSF25 Recombinant Antibody; Fab Fragment (HPAB-0788YY-F(E)) | ELISA | Humanized Fab |
HPAB-0789YY-F(E) | Human Anti-TNFRSF25 Recombinant Antibody; Fab Fragment (HPAB-0789YY-F(E)) | ELISA | Humanized Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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