Anti-Human TNFRSF25 Recombinant Antibody (11H08_H1) (CAT#: TAB-246MZ)
This antibody that specifically binds to DR3 receptors has uses in the prevention, detection, diagnosis, treatment or amelioration of a disease or disorder, especially inflammatory and autoimmune diseases, such as Crohn's disease, Inflammatory Bowel Disease, Multiple Sclerosis.
Specific Inquiry
FC
Figure 1 Flow cytometry results of 11H08 binding to hDR3-expressing HEK293F cells.
Agonist
Figuge 2 Agonist activity of the whole 11H08 antibody.
TF1 cells were treated with media and cycloheximide along with varying concentrations of the whole 11H08 immunoglobulin or 10 ng/mL of the positive control hTL1A protein, as indicated. This was compared with cells treated only with media and cycloheximide. Full length anti-DR3 antibodies act as TL1A agonists and induce cell death.
Block
Figure 3 11H08-Fab molecules block TL1A-induced cell death.
TF-1 cells were treated with 10 ng/mL hTL1A and cycloheximide, along with varying concentrations of the anti-DR3 Fab molecules H1L2-Fab, H5L2-Fab and 11H08-Fab, as indicated. As shown by the graph, H1L2-Fab, H5L2-Fab and 11H08-Fab inhibited TL1A-induced apoptosis in human TF-1 cells, showing a dose-dependent prevention of apoptosis in cycloheximide-treated TF-1 cells in the presence of TL1A.
FuncS
Figure 4 Anti-DR3 Fab-HSA molecules block TL1A-induced cytokine release.
Specifications
- Host Species
- Human
- Type
- Humanized antibody
- Specificity
- Human
- Clone
- 11H08_H1
- Applications
- Agonist, Block, FC, FuncS
- Related Disease
- Crohn's disease, colitis, Inflammatory Bowel Disease, arthritis, asthma, Multiple Sclerosis, atherosclerosis, and allergic disorders
Applications
- Application Notes
- This antibody has been reported for use in Agonist, Blocking, Flow Cytotoxicityometry, Functional Assay.
Target
- Alternative Names
- TNFRSF25; tumor necrosis factor receptor superfamily, member 25; DR3; TR3; DDR3; LARD; APO-3; TRAMP; WSL-1; WSL-LR; TNFRSF12; tumor necrosis factor receptor superfamily member 25; protein WSL-1; death receptor beta; apoptosis inducing receptor; apoptosis-inducing receptor AIR; apoptosis-mediating receptor DR3; apoptosis-mediating receptor TRAMP; death domain receptor 3 soluble form; lymphocyte-associated receptor of death; tumor necrosis factor receptor superfamily, member 12 (translocating chain-association membrane protein)
- Gene ID
- 8718
- UniProt ID
- Q93038
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Mouse Antibody Products
Humanized Antibody Products
IgG Antibody Products
ScFv Antibody Products
Fab Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-242MZ | Mouse Anti-TNFRSF25 Recombinant Antibody (TAB-242MZ) | ELISA | Mouse IgG1 |
| TAB-243MZ | Mouse Anti-TNFRSF25 Recombinant Antibody (TAB-243MZ) | ELISA | Mouse IgG1 |
| TAB-244MZ | Mouse Anti-TNFRSF25 Recombinant Antibody (TAB-244MZ) | ELISA | Mouse IgG2a |
| TAB-245MZ | Anti-Human TNFRSF25 Recombinant Antibody (11H08 ) | Agonist, Block, FC, FuncS | |
| TAB-242MZ-S(P) | Mouse Anti-TNFRSF25 Recombinant Antibody; scFv Fragment (TAB-242MZ-S(P)) | ELISA | Mouse scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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