Recombinant Mouse Anti-TOP2A Antibody (clone 1D2-2H6-7D1)
CAT#: VS3-FY1471
This product is a recombinant mouse antibody that recognizes TOP2A. This antibody has been reported for use in Immunohistochemistry-Paraffin. The clone 1D2-2H6-7D1 is specific for human TOP2A. The antigen is synthetic peptide derived from human topoisomerase iiα.




Specifications
- Immunogen
- Synthetic peptide derived from human topoisomerase IIα.
- Host Species
- Mouse
- Type
- Mouse IgG2b
- Specificity
- Human TOP2A
- Species Reactivity
- Human
- Clone
- 1D2-2H6-7D1
- Applications
- Immunohistochemistry-Paraffin
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity Chromatography
- Purity
- >95% as determined by SDS-PAGE
- Buffer
- PBS, pH 7.3, 50% glycerol, 0.5% BSA
- Preservative
- 0.02% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Immunohistochemistry-Paraffin: 1/100-1/500
Target
- Alternative Names
- DNA Topoisomerase II Alpha; Topoisomerase (DNA) II Alpha 170kDa; DNA Topoisomerase II, Alpha Isozyme; EC 5.99.1.3; TOP2; DNA Topoisomerase (ATP-Hydrolyzing)
- Gene ID
- 7153
- UniProt ID
- P11388
- Sequence Similarities
- Belongs to the type II topoisomerase family.
- Cellular Localization
- Cytoplasm, Nucleus
- Post Translation Modifications
- Phosphorylation has no effect on catalytic activity. However, phosphorylation at Ser-1106 by CSNK1D/CK1 promotes DNA cleavable complex formation.
- Protein Refseq
- NP_001058.2
- Function
- Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612).
May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation (By similarity).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
Reconstitution Buffer
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
See other products for "TOP2A"
Select a product category from the dropdown menu below to view related products.
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-3639 | Rabbit Anti-TOP2A Recombinant Antibody (clone DS3639AB) | ICC, IHC-P, WB | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-2235-CN | Rabbit Anti-TOP2A Polyclonal Antibody (MRO-2235-CN) | WB, IF, FC | Rabbit IgG |
MRO-2237-CN | Rabbit Anti-TOP2A Polyclonal Antibody (MRO-2237-CN) | WB, IF, IHC, FC | Rabbit IgG |
VS3-FY2905 | Mouse Anti-TOP2A Recombinant Antibody (VS3-FY2905) | WB, ICC, FC, ELISA | Mouse IgG |
VS7-0425-WR1033 | Mouse Anti-TOP2A Recombinant Antibody (clone 6C12G12) | WB, ICC, FC | Mouse IgG2b |
VS7-0425-WR1034 | Mouse Anti-TOP2A Recombinant Antibody (clone 6D4B2) | WB, IHC | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-YF296 | A*02:01/Human Topoisomerase II-alpha-b (FLYDDNQRV) MHC Monomer | MHC Multimer |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0525-XY7427 | Anti-TOP2A Immunohistochemistry Kit | IHC | |
VS-0525-XY7428 | Anti-Mouse TOP2A Immunohistochemistry Kit | IHC |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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