Recombinant Rabbit Anti-TXN Antibody (clone R07-4A4) (CAT#: VS3-FY1500)
This product is a recombinant rabbit antibody that recognizes TXN. This antibody has been reported for use in Western Blot. The clone R07-4A4 is specific for human, mouse, rat TXN. The antigen is synthetic peptide derived from human trx1.
Specific Inquiry
WB
Figure 1. Recombinant Rabbit Anti-TXN Antibody (clone R07-4A4) in WB.
Western Blot analysis of Thioredoxin/TRX in C6, C2C12 lysates using Thioredoxin Antibody.
Specifications
- Immunogen
- Synthetic peptide derived from human TRX1.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse, Rat TXN
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R07-4A4
- Applications
- Western Blot
- Conjugate
- Unconjugated
- MW
- Calculated MW: 12 kDa; Observed MW: 12 kDa
Product Property
- Purification
- Affinity Purified
- Purity
- >95% as determined by SDS-PAGE
- Buffer
- 50 mM Tris-Glycine, pH 7.4, 0.15 M NaCl, 40% glycerol, 0.05% BSA
- Preservative
- 0.01% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/1000-1/10000
Target
- Alternative Names
- Thioredoxin; Surface-Associated Sulphydryl Protein; ATL-Derived Factor; SASP; TRX1; TRDX
- Gene ID
- 7295
- UniProt ID
- P10599
- Sequence Similarities
- Belongs to the thioredoxin family.
- Cellular Localization
- Cytoplasm, Nucleus, Secreted
- Post Translation Modifications
- In the fully reduced protein, both Cys-69 and Cys-73 are nitrosylated in response to nitric oxide (NO). When two disulfide bonds are present in the protein, only Cys-73 is nitrosylated. Cys-73 can serve as donor for nitrosylation of target proteins.
In case of infection, ubiquitinated by S.typhimurium protein slrP, leading to its degradation.
- Protein Refseq
- NP_001231867.1; NP_003320.2
- Function
- Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.
ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Fab Antibody Products
ScFv Antibody Products
IgG Antibody Products
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Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1017-F(E) | Recombinant Anti-human TXN Antibody Fab Fragment | RIA, IF, FuncS | Fab |
| MHH-1017-F(E) | Recombinant Human Anti-human TXN Antibody Fab Fragment | IF, FC, FuncS | Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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