Anti-A2M Products

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For Research Use Only. Not For Clinical Use.

Are prolonged drug development cycles and inconsistent antibody performance hindering your research on inflammatory or neurodegenerative diseases? Creative Biolabs' Anti-A2M Recombinant Antibodies leverage cutting-edge mammalian expression systems and rigorous functional validation to deliver unparalleled specificity and batch-to-batch reproducibility. Designed for demanding applications like biomarker quantification, protein interaction studies, and therapeutic target validation, these antibodies empower researchers to overcome variability challenges and accelerate translational discoveries.

A2M: A Multifaceted Regulator of Proteolytic Cascades

Creative Biolabs' recombinant antibodies against A2M are engineered to recognize distinct conformational epitopes critical for studying its protease-trapping mechanism. With high affinity and minimal cross-reactivity, these tools enable precise detection of A2M in complex biological matrices, including serum, cerebrospinal fluid, and tumor microenvironment samples.

Alternative Names

α2M; CPAMD5; S863-7; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5.

Background

The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified.

Anti-A2M rAb Products

Creative Biolabs' antibody catalog features formats optimized for ELISA, Western blot, immunohistochemistry (IHC), and flow cytometry, with species reactivity spanning human, murine, and primate models. Designed to minimize lot-to-lot variability, these reagents guarantee consistency throughout longitudinal studies.

Table.1 Featured anti-A2M recombinant antibody products at Creative Biolabs.

Creative Quality Control

Creative Biolabs applies stringent quality control measures to all anti-A2M recombinant antibody products, with each batch thoroughly validated for specificity, sensitivity, and functional performance. This rigorous process ensures that our antibodies consistently meet the highest industry standards, delivering reliable and high-performing reagents for even the most challenging applications.

Customer Reviews

rAb Production

Our mammalian system, devoid of serum, guarantees both the precision of post-translational modifications and the ability to scale production from milligrams to grams. By incorporating AI-powered codon optimization alongside perfusion bioreactor advancements, we attain monomeric purity exceeding 95%, essential for crucial in vivo and diagnostic uses.

Featured Anti-A2M Recombinant Antibody Production Platforms
Fig.5 Production of recombinant anti-A2M antibodies on a milligram scale.

Fig.6 Synthesis of recombinant anti-A2M antibodies at gram-scale quantities.

rAb Modalities

From bispecific formats blocking A2M-protease interactions to Fc-engineered variants enhancing tissue penetration, Creative Biolabs offers customizable solutions. Delve into antibody fragments such as Fab and scFv, various IgG subclasses, and conjugated derivatives, all customized to fit your experimental requirements.

Fig.7 Full-length anti-A2M recombinant antibody production and modalities.

Creative Biolabs is dedicated to advancing your research with superior anti-A2M recombinant antibody offerings. Our pursuit of scientific excellence and commitment to client satisfaction drive us to deliver innovative solutions. If you are interested in our products or wish to discuss your specific project requirements, please reach out to us. Our team of experts stands prepared to assist you in achieving your research goals.