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    ANGPTL3

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    For Research Use Only. Not For Clinical Use.


    This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metabolism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2.
    ANGPTL3
    Protein class

    Disease related genes, Human disease related genes, Plasma proteins

    Predicted location

    Secreted

    Single cell type specificity

    Group enriched (Hepatocytes, Proximal tubular cells)

    Immune cell specificity

    Not detected in immune cells

    Cell line specificity

    Not detected

    Interaction

    Interacts with ANGPTL8. Interacts with ITGB3 (By similarity).

    Molecular function

    Heparin-binding

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