Human Anti-ANGPTL3 scFv-Fc Chimera (VS-0425-FY32) (CAT#: VS-0425-FY32)
anti-ANGPTL3 scFv-Fc antibody is a recombinant human antibody that can specifically recognize ANGPTL3. ANGPTL3 is an important signaling factor involved in various biological processes such as cell proliferation, differentiation, and apoptosis. The antibody specifically binds to ANGPTL3 through its single-chain variable fragment (scFv) domain, and the Fc fragment endows it with the ability to interact with immune effector molecules such as Fc receptors and the complement system. This antibody has potential applications in studying the function and mechanism of ANGPTL3 and may serve as a potential target for treating related diseases.
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Normal Tissue
Figure 1 IHC staining of human liver
(Immunohistochemical staining of human liver shows strong cytoplasmic positivity in hepatocytes.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/38097/ihc_selected.jpg
(Immunohistochemical staining of human liver shows strong cytoplasmic positivity in hepatocytes.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/38097/ihc_selected.jpg
Figure 2 Cerebral cortex
(Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/38097/78355_B_9_5.jpg
(Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/38097/78355_B_9_5.jpg
Figure 3 Colon
(Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/38097/78639_A_8_3.jpg
(Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/38097/78639_A_8_3.jpg
Figure 4 Liver
(Hepatocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/38097/78639_A_9_4.jpg
(Hepatocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/38097/78639_A_9_4.jpg
Figure 5 Kidney
(Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/38097/78639_A_8_5.jpg
(Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/38097/78639_A_8_5.jpg
Figure 6 Testis
(Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Sertoli cells Staining: Medium Intensity: Strong Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/38097/78639_A_4_6.jpg
(Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Sertoli cells Staining: Medium Intensity: Strong Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/38097/78639_A_4_6.jpg
Specifications
- Immunogen
- Human ANGPTL3 as an immunogen.
- Host Species
- Human
- Type
- Human IgG4, scFv-Fc
- Specificity
- Human ANGPTL3
- Species Reactivity
- Human
- Applications
- ELISA
- Related Disease
- Atherosclerosis Therapy; Lipoprotein Disorders
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Angiopoietin Like 3; Angiopoietin 5; ANGPT5; ANG-5; Angiopoietin-Related Protein 3; Angiopoietin-Like Protein 3
- Gene ID
- 27329
- UniProt ID
- Q9Y5C1
- Long Name
- Angiopoietin Like 3
- Cellular Localization
- Secreted, Cell projection, lamellipodium
- Post Translation Modifications
- O-glycosylated at Thr-226 by GALNT2; blocks processing and activation by proprotein convertases.
In part proteolytically cleaved by proprotein convertases; proposed to be involved in activation.
Glycosylation at Asn23, Asn115, Thr226, Asn296, and Asn357
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect ANGL3_HUMAN (1010)
Glycosylation from GlyGen 8 sites, 2 N-linked glycans (3 sites), 3 O-linked glycans (3 sites)
- Protein Refseq
- NP_055310.1
- Function
- Acts in part as a hepatokine that is involved in regulation of lipid and glucose metabolism.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H30 | Anti-Human ANGPTL3 Recombinant Antibody | IF, IP, Neut, FuncS, ELISA, FC, ICC | IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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