Human Anti-ANGPTL3 scFv-Fc Chimera (VS-0425-FY32)
CAT#: VS-0425-FY32
anti-ANGPTL3 scFv-Fc antibody is a recombinant human antibody that can specifically recognize ANGPTL3. ANGPTL3 is an important signaling factor involved in various biological processes such as cell proliferation, differentiation, and apoptosis. The antibody specifically binds to ANGPTL3 through its single-chain variable fragment (scFv) domain, and the Fc fragment endows it with the ability to interact with immune effector molecules such as Fc receptors and the complement system. This antibody has potential applications in studying the function and mechanism of ANGPTL3 and may serve as a potential target for treating related diseases.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human liver
Immunohistochemical staining of human liver shows strong cytoplasmic positivity in hepatocytes.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/38097/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/38097/78355_B_9_5.jpg
Normal Tissue
Figure 3 Colon
Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/38097/78639_A_8_3.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/38097/78639_A_9_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/38097/78639_A_8_5.jpg
Normal Tissue
Figure 6 Testis
Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Sertoli cells Staining: Medium Intensity: Strong Quantity: <25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/38097/78639_A_4_6.jpg
❮
❯
Specifications
- Immunogen
- Human ANGPTL3 as an immunogen.
- Host Species
- Human
- Type
- Human IgG4, scFv-Fc
- Specificity
- Human ANGPTL3
- Species Reactivity
- Human
- Applications
- ELISA
- Related Disease
- Atherosclerosis Therapy; Lipoprotein Disorders
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Angiopoietin Like 3; Angiopoietin 5; ANGPT5; ANG-5; Angiopoietin-Related Protein 3; Angiopoietin-Like Protein 3
- Gene ID
- 27329
- UniProt ID
- Q9Y5C1
- Long Name
- Angiopoietin Like 3
- Cellular Localization
- Secreted, Cell projection, lamellipodium
- Post Translation Modifications
- O-glycosylated at Thr-226 by GALNT2; blocks processing and activation by proprotein convertases.
In part proteolytically cleaved by proprotein convertases; proposed to be involved in activation.
Glycosylation at Asn23, Asn115, Thr226, Asn296, and Asn357
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect ANGL3_HUMAN (1010)
Glycosylation from GlyGen 8 sites, 2 N-linked glycans (3 sites), 3 O-linked glycans (3 sites)
- Protein Refseq
- NP_055310.1
- Function
- Acts in part as a hepatokine that is involved in regulation of lipid and glucose metabolism.
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-0425-FY32. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "ANGPTL3"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H30 | Anti-Human ANGPTL3 Recombinant Antibody | IF, IP, Neut, FuncS, ELISA, FC, ICC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0900CLV-S(P) | Mouse Anti-ANGPTL3 Recombinant Antibody; scFv Fragment (TAB-0900CLV-S(P)) | ELISA, Neut, FuncS | Mouse scFv |
| TAB-0901CLV-S(P) | Mouse Anti-ANGPTL3 Recombinant Antibody; scFv Fragment (TAB-0901CLV-S(P)) | ELISA, Neut, FuncS | Mouse scFv |
| TAB-0902CLV-S(P) | Mouse Anti-ANGPTL3 Recombinant Antibody; scFv Fragment (TAB-0902CLV-S(P)) | ELISA, Neut, FuncS | Mouse scFv |
| TAB-0903CLV-S(P) | Mouse Anti-ANGPTL3 Recombinant Antibody; scFv Fragment (TAB-0903CLV-S(P)) | ELISA, Neut, FuncS | Mouse scFv |
| TAB-0904CLV-S(P) | Mouse Anti-ANGPTL3 Recombinant Antibody; scFv Fragment (TAB-0904CLV-S(P)) | ELISA, Neut, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0171 | Hi-Affi™ Rabbit Anti-ANGPTL3 Recombinant Antibody (clone DS171AB) | WB, ICC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0187-FY | Human Anti-ANGPTL3 Recombinant Antibody (HPAB-0187-FY) | Inhib | Human IgG4, κ |
| HPAB-0221-FY | Human Anti-ANGPTL3 Recombinant Antibody (HPAB-0221-FY) | ELISA, Inhib | Human IgG |
| HPAB-0222-FY | Human Anti-ANGPTL3 Recombinant Antibody (HPAB-0222-FY) | ELISA, Inhib | Human IgG |
| VS-0723-WK210 | Rabbit Anti-ANGPTL3 Recombinant Antibody (VS-0723-WK210) | ELISA, FC | Rabbit IgG |
| VS13-YC50 | Rabbit Anti-ANGPTL3 Recombinant Antibody (VS13-YC50) | WB, IHC-P, IHC-Fr, ICC, IF, ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0187-FY-S(P) | Human Anti-ANGPTL3 Recombinant Antibody (HPAB-0187-FY-S(P)); scFv Fragment | Inhib | Human scFv |
| HPAB-0221-FY-S(P) | Human Anti-ANGPTL3 Recombinant Antibody scFv Fragment (HPAB-0221-FY-S(P)) | ELISA, Inhib | Human scFv |
| HPAB-0222-FY-S(P) | Human Anti-ANGPTL3 Recombinant Antibody scFv Fragment (HPAB-0222-FY-S(P)) | ELISA, Inhib | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0187-FY-F(E) | Human Anti-ANGPTL3 Recombinant Antibody (HPAB-0187-FY-F(E)); Fab Fragment | Inhib | Human Fab |
| HPAB-0221-FY-F(E) | Human Anti-ANGPTL3 Recombinant Antibody Fab Fragment (HPAB-0221-FY-F(E)) | ELISA, Inhib | Human Fab |
| HPAB-0222-FY-F(E) | Human Anti-ANGPTL3 Recombinant Antibody Fab Fragment (HPAB-0222-FY-F(E)) | ELISA, Inhib | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY375 | Anti-ANGPTL3 Immunohistochemistry Kit | IHC | |
| VS-0525-XY376 | Anti-Mouse ANGPTL3 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC15 | Recombinant Anti-ANGPTL3 Eliminating Antibody, pH-Sensitive (VS-0625-YC15) | Antigen-Sweeping In Vivo. | Human IgG1 |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: IF, IP, Neut, FuncS, ELISA, FC, WB
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: FC, IP, ELISA, Neut, FuncS, IF, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
Application: ELISA, FC, IP, FuncS, IF, Neut, WB
Application: FC, IP, ELISA, Neut, FuncS, IF, IHC
Application: ELISA, FC
Application: Neut, FC
Application: Neut, ELISA, IF, IP, FuncS, FC
Application: ELISA, FuncS, Neut, IF, WB, EM, Inhib, IHC
Application: ELISA, Neut
Application: ELISA, Vaccine, FuncS
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
