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    ANGPTL4

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    For Research Use Only. Not For Clinical Use.


    Background

    This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and insulin sensitivity. This protein can also act as an apoptosis survival factor for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion. The C-terminal domain may be proteolytically-cleaved from the full-length secreted protein. Decreased expression of this gene has been associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4.
    Protein class

    Metabolic proteins, Plasma proteins

    Predicted location

    Intracellular, Secreted (different isoforms)

    Single cell type specificity

    Cell type enhanced (Basal respiratory cells, Pancreatic endocrine cells, Skeletal myocytes, Hepatocytes, Proximal enterocytes)

    Immune cell specificity

    Immune cell enhanced (basophil)

    Cell line specificity

    Cell line enhanced (ASC diff, HBEC3-KT, LHCN-M2, TIME, U-138 MG)

    Interaction

    Homooligomer; disulfide-linked via Cys residues in the N-terminal part of the protein (PubMed:19270337). The homooligomer undergoes proteolytic processing to release the ANGPTL4 C-terminal chain, which circulates as a monomer (PubMed:19270337). The homooligomer unprocessed form is able to interact with the extracellular matrix (PubMed:21398697).

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