Human Anti-ANGPTL4 scFv-Fc Chimera (VS-0425-FY33) (CAT#: VS-0425-FY33)

• Immunogen
• Recombinant human ANGPTL4 protein as the immunogen.

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Specificity
• Human ANGPTL4

• Species Reactivity
• Human, Cynomolgus monkey, Rat, Mouse

• Applications
• Inhibition, ELISA

• Related Disease
• Cardiovascular disease or disorders; such as atherosclerosis; aneurysm; hypertension; angina; stroke; cerebrovascular disease; congestive heart failure; coronary artery disease; myocardial infarction; peripheral vascular disease

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• The optimal dilution concentration is determined by the experiment.

• Alternative Names
• Angiopoietin Like 4; Hepatic Fibrinogen/Angiopoietin-Related Protein; Peroxisome Proliferator-Activated Receptor (PPAR) Gamma Induced Angiopoietin-Related Protein; Hepatic Angiopoietin-Related Protein; PPARG Angiopoietin Related Protein; Fasting-Induced Adipose Factor; Angiopoietin-Related Protein 4; HFARP; Arp4; PGAR

• Gene ID
• 51129

• UniProt ID
• Q9BY76

• Long Name
• Angiopoietin Like 4

• Cellular Localization
• Secreted

• Post Translation Modifications
• N-glycosylated.
  [ANGPTL4 N-terminal chain]: Forms disulfide-linked dimers and tetramers.
  Cleaved into a smaller N-terminal chain and a larger chain that contains the fibrinogen C-terminal domain; both cleaved and uncleaved forms are detected in the extracellular space.
  The cleaved form is not present within the cell.
  Glycosylation at Asn177
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyConnect ANGL4_HUMAN (1918)
  Glycosylation from GlyGen 4 sites, 22 N-linked glycans (1 site), 3 O-linked glycans (3 sites)

• Protein Refseq
• XP_005272541.1; XP_005272542.1; XP_054177121.1; XP_054177122.1; NP_001034756.1

• Function
• Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism.
  May also play a role in regulating glucose homeostasis and insulin sensitivity (Probable).
  Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage.
  Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stress fibers and focal adhesions in endothelial cells that have adhered to ANGPTL4-containing ECM (in vitro).

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