Human Anti-ANGPTL4 scFv-Fc Chimera (VS-0425-FY33)
CAT#: VS-0425-FY33
anti-ANGPTL4 scFv-Fc antibody is an innovative biopharmaceutical designed to target the key molecule ANGPTL4 (Angiopoietin-like protein 4). ANGPTL4 plays a significant role in various diseases, including cardiovascular diseases, diabetes, obesity, and cancer. By specifically binding and neutralizing ANGPTL4, the anti-ANGPTL4 scFv-Fc antibody is expected to offer new therapeutic options for these diseases.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7879/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human kidney
Immunohistochemical staining of human kidney shows moderate cytoplasmic positivity in cells in tubules.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/33770/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/33770/152720_B_9_5.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/33770/152720_A_8_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear Leydig cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/33770/152720_A_5_6.jpg
Normal Tissue
Figure 6 Placenta
Decidual cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/33770/152720_A_1_7.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (ASC diff, HBEC3-KT, LHCN-M2, TIME, U-138 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000167772-ANGPTL4
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Specifications
- Immunogen
- Recombinant human ANGPTL4 protein as the immunogen.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human ANGPTL4
- Species Reactivity
- Human, Cynomolgus monkey, Rat, Mouse
- Applications
- Inhibition, ELISA
- Related Disease
- Cardiovascular disease or disorders; such as atherosclerosis; aneurysm; hypertension; angina; stroke; cerebrovascular disease; congestive heart failure; coronary artery disease; myocardial infarction; peripheral vascular disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Angiopoietin Like 4; Hepatic Fibrinogen/Angiopoietin-Related Protein; Peroxisome Proliferator-Activated Receptor (PPAR) Gamma Induced Angiopoietin-Related Protein; Hepatic Angiopoietin-Related Protein; PPARG Angiopoietin Related Protein; Fasting-Induced Adipose Factor; Angiopoietin-Related Protein 4; HFARP; Arp4; PGAR
- Gene ID
- 51129
- UniProt ID
- Q9BY76
- Long Name
- Angiopoietin Like 4
- Cellular Localization
- Secreted
- Post Translation Modifications
- N-glycosylated.
[ANGPTL4 N-terminal chain]: Forms disulfide-linked dimers and tetramers.
Cleaved into a smaller N-terminal chain and a larger chain that contains the fibrinogen C-terminal domain; both cleaved and uncleaved forms are detected in the extracellular space.
The cleaved form is not present within the cell.
Glycosylation at Asn177
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect ANGL4_HUMAN (1918)
Glycosylation from GlyGen 4 sites, 22 N-linked glycans (1 site), 3 O-linked glycans (3 sites)
- Protein Refseq
- XP_005272541.1; XP_005272542.1; XP_054177121.1; XP_054177122.1; NP_001034756.1
- Function
- Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism.
May also play a role in regulating glucose homeostasis and insulin sensitivity (Probable).
Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage.
Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stress fibers and focal adhesions in endothelial cells that have adhered to ANGPTL4-containing ECM (in vitro).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2890z | Mouse Anti-ANGPTL4 Recombinant Antibody (clone 42C3) | WB, ELISA, IHC | Mouse IgG1, κ |
| HPAB-0315-FY | Mouse Anti-ANGPTL4 Recombinant Antibody (HPAB-0315-FY) | ELISA | Mouse IgG |
| HPAB-0316-FY | Mouse Anti-ANGPTL4 Recombinant Antibody (HPAB-0316-FY) | ELISA | Mouse IgG |
| HPAB-0317-FY | Mouse Anti-ANGPTL4 Recombinant Antibody (HPAB-0317-FY) | ELISA | Mouse IgG |
| HPAB-0318-FY | Mouse Anti-ANGPTL4 Recombinant Antibody (HPAB-0318-FY) | ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0906CLV | Human Anti-ANGPTL4 Recombinant Antibody (TAB-0906CLV) | ELISA | Human IgG1 |
| TAB-0906CLV-F(E) | Human Anti-ANGPTL4 Recombinant Antibody; Fab Fragment (TAB-0906CLV-F(E)) | ELISA | Human Fab |
| TAB-0906CLV-S(P) | Human Anti-ANGPTL4 Recombinant Antibody; scFv Fragment (TAB-0906CLV-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0907CLV-F(E) | Mouse Anti-ANGPTL4 Recombinant Antibody; Fab Fragment (TAB-0907CLV-F(E)) | FC, Block, FuncS | Mouse Fab |
| TAB-0908CLV-F(E) | Mouse Anti-ANGPTL4 Recombinant Antibody; Fab Fragment (TAB-0908CLV-F(E)) | ELISA | Mouse Fab |
| TAB-0909CLV-F(E) | Mouse Anti-ANGPTL4 Recombinant Antibody; Fab Fragment (TAB-0909CLV-F(E)) | ELISA, FuncS, Inhib | Mouse Fab |
| TAB-0910CLV-F(E) | Mouse Anti-ANGPTL4 Recombinant Antibody; Fab Fragment (TAB-0910CLV-F(E)) | FuncS, Inhib | Mouse Fab |
| TAB-0911CLV-F(E) | Mouse Anti-ANGPTL4 Recombinant Antibody; Fab Fragment (TAB-0911CLV-F(E)) | FuncS, Inhib | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0172 | Hi-Affi™ Rabbit Anti-ANGPTL4 Recombinant Antibody (clone DS172AB) | WB | Rabbit IgG |
| MOR-4507 | Hi-Affi™ Rabbit Anti-ANGPTL4 Recombinant Antibody (clone TH15DS) | WB, IF, ICC, ELISA, pep-ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0113CQ-S(P) | Human Anti-ANGPTL4 Recombinant Antibody; scFv Fragment (HPAB-0113CQ-S(P)) | ELISA, Neut | Human scFv |
| HPAB-0114CQ-S(P) | Mouse Anti-ANGPTL4 Recombinant Antibody; scFv Fragment (HPAB-0114CQ-S(P)) | ELISA, Neut | Mouse scFv |
| HPAB-1479-FY-F(E) | Mouse Anti-ANGPTL4 Recombinant Antibody (HPAB-1479-FY-F(E)); Fab Fragment | ELISA | Mouse Fab |
| HPAB-1480-FY-F(E) | Mouse Anti-ANGPTL4 Recombinant Antibody (HPAB-1480-FY-F(E)); Fab Fragment | ELISA | Mouse Fab |
| HPAB-1481-FY-F(E) | Mouse Anti-ANGPTL4 Recombinant Antibody (HPAB-1481-FY-F(E)); Fab Fragment | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0315-FY-F(E) | Mouse Anti-ANGPTL4 Recombinant Antibody Fab Fragment (HPAB-0315-FY-F(E)) | ELISA | Mouse Fab |
| HPAB-0316-FY-F(E) | Mouse Anti-ANGPTL4 Recombinant Antibody Fab Fragment (HPAB-0316-FY-F(E)) | ELISA | Mouse Fab |
| HPAB-1479-FY-S(P) | Mouse Anti-ANGPTL4 Recombinant Antibody (HPAB-1479-FY-S(P)); scFv Fragment | ELISA | Mouse scFv |
| HPAB-1480-FY-S(P) | Mouse Anti-ANGPTL4 Recombinant Antibody (HPAB-1480-FY-S(P)); scFv Fragment | ELISA | Mouse scFv |
| HPAB-1481-FY-S(P) | Mouse Anti-ANGPTL4 Recombinant Antibody (HPAB-1481-FY-S(P)); scFv Fragment | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY377 | Anti-ANGPTL4 Immunohistochemistry Kit | IHC |
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