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ANTXR1

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Anti-ANTXR1 Products

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For Research Use Only. Not For Clinical Use.


Predicted to enable actin filament binding activity; collagen binding activity; and transmembrane signaling receptor activity. Acts upstream of or within blood vessel development; negative regulation of extracellular matrix assembly; and positive regulation of metallopeptidase activity. Predicted to be located in external side of plasma membrane; filopodium membrane; and lamellipodium membrane. Predicted to be active in cell surface and plasma membrane. Is expressed in several structures, including brain; chondrocranium; costal cartilage; immune system; and liver. Human ortholog(s) of this gene implicated in GAPO syndrome and colorectal carcinoma. Orthologous to human ANTXR1 (ANTXR cell adhesion molecule 1).
Protein class

Disease related genes, Human disease related genes, Plasma proteins

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Oligodendrocyte precursor cells, Astrocytes, Skeletal myocytes, Endometrial stromal cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (LHCN-M2, TIME)

Interaction

Interacts with gelatin and type 1 collagen. Interacts with the actin cytoskeleton. (Microbial infection) Interacts (via VWFA domain) with the protective antigen (PA) of B.anthracis (PubMed:11700562, PubMed:12700348, PubMed:16762926, PubMed:20585457). Binding does not occur in the presence of calcium (PubMed:11700562, PubMed:12700348, PubMed:16762926, PubMed:20585457).

Molecular function

Receptor

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