Anti-APLP2 Products

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For Research Use Only. Not For Clinical Use.

Explore the world of anti-APLP2 antibodies with Creative Biolabs as your go-to source for high-quality research reagents. Dive into an in-depth exploration of Amyloid-Like Protein 2 (APLP2), a prominent member of the amyloid precursor protein family, which is actively involved in the intricate processes of maintaining synapse function and contributes to the development of cancer. Unlock the potential of APLP2 research with our rigorously validated antibodies, carefully designed and produced for unparalleled specificity and reliability in understanding the roles of this transmembrane protein.

APLP2: A Target Involved in Synapse Function and Cancer

Amyloid-Like Protein 2 (APLP2) is a transmembrane protein that is a structural and functional counterpart of the well-known amyloid precursor protein (APP). While APP is the prototypical member of its family, APLP2 is deeply implicated in the biological functions at synapses and can compensate for APP loss. In the context of neurodegeneration, this protein has been shown to be a crucial player in the pathogenesis of Alzheimer's disease. On the other hand, APLP2 is found to be overexpressed and linked to enhanced proliferation and metastasis in various cancers, including pancreatic and cutaneous squamous cell carcinoma. Due to its dual involvement in both neural health and malignancy, APLP2 presents itself as an attractive therapeutic and diagnostic target.

Background

This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Anti-APLP2 rAb Products

Our anti-APLP2 recombinant antibodies are engineered to recognize precise epitopes with high affinity and specificity. Offering clean, robust signals with minimal background, these reagents are reliable tools for your APLP2 research to generate credible data. Expect nothing less than reproducible, high-quality performance from our antibodies that you can trust to advance your work.

Table 1. Featured anti-APLP2 recombinant antibody products at Creative Biolabs.

Creative Quality Control

Creative Biolabs doesn't just supply antibodies, we help you ensure the validity of your work. Every anti-APLP2 antibody has undergone our extensive quality control process that has been developed over years of experience. We utilize a suite of validation tests, including Western Blot with relevant cell lysates and immunocytochemistry, to confirm outstanding specificity and performance. This process is your assurance that our antibodies can provide the high-quality data you need to be confident in your conclusions and work more efficiently.

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rAb Production

Creative Biolabs produces anti-APLP2 antibodies through advanced recombinant DNA technology to ensure unmatched batch-to-batch consistency.

Featured Anti-APLP2 Recombinant Antibody Production Platforms
Fig.2 Milligram-scale anti-APLP2 recombinant antibody production.

Fig.3 Gram-scale anti-APLP2 recombinant antibody production.

rAb Modalities

Creative Biolabs stocks a wide range of ready-to-use, high-quality anti-APLP2 recombinant antibodies and offers custom services to make your ideal antibody. We have a variety of modalities to choose from, including full-length IgG, Fab, and scFv fragments.

Fig.4 Full-length anti-APLP2 recombinant antibody production and modalities.

APLP2-Targeted Drug Information

Table 2. Public drug targeting APLP2.

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

Creative Biolabs is committed to providing the scientific community with all the tools it needs to advance research into the various biological roles of APLP2. With our range of high-performance recombinant antibodies, you have the precision required to discover more about its function in neurobiology and cancer. Our validated products will help you unlock new insights into disease mechanisms. Don't hesitate to contact our scientific team to learn more about how our products can support your work.