Loading...
ATIC
This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria.
Protein class
Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Cytotrophoblasts, Extravillous trophoblasts)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Homodimer (PubMed:14756553, PubMed:14966129). Associates with internalized INSR complexes on Golgi/endosomal membranes (PubMed:25687571). Interacts with INSR; ATIC together with PRKAA2/AMPK2 and HACD3/PTPLAD1 is proposed to be part of a signaling network regulating INSR autophosphorylation and endocytosis (PubMed:25687571).
Molecular function
Hydrolase, Multifunctional enzyme, Transferase
More Types Infomation
- PE-A*02:01/Human ATIC (NLYPFVKTV) MHC Tetramer (MHC-LC1936)
-
- Class: Class I
- Antigen: ATIC
- Antigen Species: Human
- Peptide: NLYPFVKTV
- Conjugate: PE
-
- Derivation: Mouse
- Species Reactivity: Human, Rabbit
- Type: Mouse IgG1
- Application: ELISA, WB
-
- Derivation: Mouse
- Species Reactivity: Human, Mouse, Monkey, Rat
- Type: Mouse IgG1
- Application: WB
- Mouse Anti-ATIC Antibody (clone F38 P7 H9) (ZG-0825F)
-
- Species Reactivity: Human, Frog, Fruit Fly, Rat, Mouse
- Type: Mouse IgG1
- Application: WB, IHC
-
- Species Reactivity: Human, Rabbit
- Type: Mouse IgG
- Application: WB
-
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG
- Application: WB
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag
For Research Use Only. Not For Clinical Use.