Anti-ATIC Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs offers premium anti-ATIC recombinant antibodies to support cancer research and immunology. ATIC, a bifunctional enzyme in the de novo purine biosynthesis pathway, has been a target of chemotherapy for many years, and has been identified as a regulator of inflammatory signaling. Our top-quality antibodies to ATIC are invaluable for studies of nucleotide metabolism, novel anti-cancer drug discovery, and signaling in cells.

ATIC: A Bifunctional Enzyme in Purine Synthesis

5-Aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) is a cytosolic enzyme that carries out the last two reactions in the de novo synthesis of purine nucleotides. This enzyme converts FAICAR to inosine monophosphate (IMP), the first common precursor for AMP and GMP. Proliferating cells require building blocks for DNA and RNA. In particular, they depend on a constant supply of IMP from the action of ATIC. For this reason, the enzyme has been a longstanding target of antifolate chemotherapy drugs, such as methotrexate. But the essentiality of ATIC extends beyond its metabolic role. ATIC has been shown to bind to and regulate other signaling proteins, with important consequences for cellular signaling.

Alternative Names

PURH; AICAR; AICARFT; IMPCHASE; HEL-S-70p

Background

Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and ATIC, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. Two transcript variants encoding different isoforms have been found for this gene.

Anti-ATIC rAb Products

Creative Biolabs' anti-ATIC recombinant antibodies (rAbs) are designed to have high specificity and robust performance. These antibodies are thoroughly validated to specifically detect the ATIC enzyme in cell lysates. Optimized for Western Blot detection of expression levels and co-immunoprecipitation experiments to study protein-protein interactions, these rAbs offer the reliability you need for cancer and immunology research.

Table 1. Featured anti-ATIC recombinant antibody products at Creative Biolabs.

Creative Quality Control

Creative Biolabs is built on quality. The production of our anti-ATIC recombinant antibodies is overseen by an extensive quality assurance process. Each lot is tested for purity and binding affinity, as well as validated performance in applications such as Western Blot and co-immunoprecipitation, so you get a reliable reagent that can be counted on to give clear, reproducible results.

Customer Reviews

rAb Production

Creative Biolabs' cutting edge production platforms are designed with your specialized needs in mind. The anti-ATIC recombinant antibodies are expressed in optimized systems that have been designed to make sure they recognize the native bifunctional enzyme, so you get a highly specific and active antibody for your experiments.

Featured Anti-ATIC Recombinant Antibody Production Platforms
Fig.3 Milligram-scale anti-ATIC recombinant antibody production.

Fig.4 Gram-scale anti-ATIC recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to empowering discovery in the research community by providing flexible antibody modalities. Our anti-ATIC recombinant antibodies can be made to order in a variety of customizable modalities, allowing researchers everywhere to study this important metabolic enzyme.

Fig.5 Full-length anti-ATIC recombinant antibody production and modalities.

Learn more about the important roles that ATIC plays in metabolism and signaling with Creative Biolabs' recombinant antibodies. We stand out with our high quality, high specificity reagents that are extensively validated, so you can be sure to get the right tool for your research. Choose Creative Biolabs for quality that moves science forward. Speak to our experts today.