ATP2A2
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Loading...- Rabbit Anti-ATP2A2 Recombinant Antibody (clone JM10-20) (MRO-1379-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
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- Anti-Mouse ATP2A2 Immunohistochemistry Kit (VS-0525-XY613)
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- Species Reactivity: Human, Mouse, Rat, Porcine, Porcine, Rabbit, Sheep
- Target: ATP2A2
- Application: IHC
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- Anti-ATP2A2 Immunohistochemistry Kit (VS-0325-XY202)
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- Species Reactivity: Human, Mouse, Rat
- Target: ATP2A2
- Application: IHC
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- Anti-Human ATP2A2 Immunohistochemistry Kit (VS-0525-XY612)
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- Species Reactivity: Human
- Target: ATP2A2
- Application: IHC
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- Anti-Canine ATP2A2 Immunohistochemistry Kit (VS-0525-XY614)
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- Species Reactivity: Human, Mouse, Rat, Canine
- Target: ATP2A2
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms.
Protein class
Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Transporters
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enriched (Cardiomyocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts with sarcolipin (SLN); the interaction inhibits ATP2A2 Ca(2+) affinity (PubMed:28890335). Interacts with phospholamban (PLN); the interaction inhibits ATP2A2 Ca(2+) affinity (PubMed:28890335). Interacts with myoregulin (MRLN) (By similarity). Interacts with DWORF (By similarity). Interacts with HAX1 (PubMed:18971376). Interacts with S100A8 and S100A9 (By similarity). Interacts with SLC35G1 and STIM1 (PubMed:22084111). Interacts with TMEM203 (PubMed:25996873). Interacts with TMEM64 and PDIA3 (By similarity). Interacts with TMX2. Interacts with VMP1; VMP1 competes with PLN and SLN to prevent them from forming an inhibitory complex with ATP2A2 (PubMed:28890335). Interacts with ULK1 (PubMed:28890335). Interacts with S100A1 in a Ca(2+)-dependent manner (PubMed:12804600). Interacts with TUNAR (By similarity). [Isoform 1]: Interacts with TRAM2 (via C-terminus).
Molecular function
Translocase
More Types Infomation
Related Signaling Pathways
cAMP Signaling Pathway
Related Diseases
Morphine Addiction