Anti-BCHE Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is a recognized expert in pharmacology and toxicology research, and our premium anti-BCHE recombinant antibodies are designed for maximum sensitivity. Butyrylcholinesterase (BCHE) is a major plasma enzyme in humans with a well-known function of hydrolyzing choline esters, and also metabolizing a number of clinically important drugs. Our high quality antibodies are essential tools for research into its pharmacogenomics, as a bioscavenger of nerve agents, or in its emerging role in Alzheimer’s disease.

BCHE: The "Pseudo" Cholinesterase of Human Plasma

BCHE, also known as pseudocholinesterase, is a serine hydrolase that is highly expressed in the liver and secreted into the blood where it is present in a concentration ten-fold higher than acetylcholinesterase (AChE). Although it is related in structure to AChE, the enzyme that rapidly degrades acetylcholine at neuronal synapses, BCHE is not found in the nervous system and is not primarily involved in cholinergic neurotransmission. It is known to hydrolyze acetylcholine, but its predominant physiological function is to scavenge and hydrolyze other choline esters and xenobiotics. Clinically, BCHE is important for two main reasons: 1) it is responsible for the metabolism of the muscle relaxant drug succinylcholine, and genetic variants with low enzyme activity cause prolonged paralysis in patients following surgery; 2) it can bind to, and inactivate highly toxic organophosphate nerve agents such as sarin or VX.

Alternative Names

Butyrylcholinesterase; Acylcholine Acylhydrolase; Cholinesterase (Serum) 2; Butyrylcholine Esterase; Pseudocholinesterase; Choline Esterase II; Cholinesterase 1;

Background

Mutant alleles at the BCHE locus are responsible for suxamethonium sensitivity. Homozygous persons sustain prolonged apnea after administration of the muscle relaxant suxamethonium in connection with surgical anesthesia. The activity of pseudocholinesterase in the serum is low and its substrate behavior is atypical. In the absence of the relaxant, the homozygote is at no known disadvantage.

Anti-BCHE rAb Products

Creative Biolabs’ recombinant antibodies are made for superior specificity and performance. They are fully validated to reliably detect endogenous BCHE in plasma and serum. Our BCHE rAbs are also optimized for ELISA to enable quantification, or for Western Blot applications. The highest quality antibodies for pharmacology and clinical chemistry research.

Table 1. Featured anti-BCHE recombinant antibody products at Creative Biolabs.

Creative Quality Control

Creative Biolabs is uncompromising when it comes to quality. The production of our anti-BCHE recombinant antibodies is tightly controlled by a quality assurance system. Lots are extensively tested for purity, specificity (no cross-reaction with AChE), and reproducible performance in validated plasma samples to ensure you always receive a top-quality, reliable reagent.

Customer Reviews

rAb Production

Accelerate your pharmacology research with Creative Biolabs’ cutting-edge production technologies. Our anti-BCHE recombinant antibodies are engineered to the highest possible standards to give you the best specificity and sensitivity for this important plasma enzyme.

Featured Anti-BCHE Recombinant Antibody Production Platforms
Fig.3 Milligram-scale anti-BCHE recombinant antibody production.

Fig.4 Gram-scale anti-BCHE recombinant antibody production.

rAb Modalities

Creative Biolabs is dedicated to providing the research community with flexible and innovative tools. Our anti-BCHE antibodies are available as a fully validated matched pair for ELISA or as recombinant antibody formats optimized for other applications to help you study its biological and toxicological functions.

Fig.5 Full-length anti-BCHE recombinant antibody production and modalities.

Take your pharmacology research to the next level with Creative Biolabs’ unmatched anti-BCHE recombinant antibodies. Our portfolio is characterized by the highest possible specificity and extensive validation, giving you the ideal tools for diagnostics and drug discovery. Let us be part of your research. Contact our experts today.