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BCHE

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For Research Use Only. Not For Clinical Use.


Background

Mutant alleles at the BCHE locus are responsible for suxamethonium sensitivity. Homozygous persons sustain prolonged apnea after administration of the muscle relaxant suxamethonium in connection with surgical anesthesia. The activity of pseudocholinesterase in the serum is low and its substrate behavior is atypical. In the absence of the relaxant, the homozygote is at no known disadvantage.
Protein class

Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Group enriched (Hepatocytes, Oligodendrocyte precursor cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enriched (Karpas-707)

Interaction

Homotetramer; disulfide-linked. Dimer of dimers.

Molecular function

Hydrolase, Serine esterase

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