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BTLA
This gene encodes a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune response. Alternative splicing results in multiple transcript variants. Polymorphisms in this gene have been associated with an increased risk of rheumatoid arthritis.
Protein class
CD markers
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enriched (B-cells)
Immune cell specificity
Group enriched (naive B-cell, memory B-cell, plasmacytoid DC)
Cell line specificity
Cell line enhanced (U-698)
Interaction
Interacts with tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:12796776, PubMed:14652006). Interacts with TNFRSF14/HVEM (via cysteine-rich domain 1) (PubMed:15568026, PubMed:18193050, PubMed:19915044).
Molecular function
Receptor
More Types Infomation
- Mouse Anti-BTLA Antibody (clone HMBT-6B2), mRNA (FAMAB-1593CQ-mRNA)
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- Species Reactivity: Mouse
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- Recombinant Mouse Anti-BTLA Antibody (VS-0923-FY23) (VS-0923-FY23)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB
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- Recombinant Mouse Anti-Human BTLA Antibody (MOB-2352MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
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- Human Anti-BTLA Antibody, mRNA (TAB-076CL-mRNA)
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- Species Reactivity: Human
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- Human Anti-BTLA Recombinant Antibody (clone Icatolimab) (VS-0723-WK43)
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) IgG4
- Application: ELISA, FC
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- Mouse Anti-BTLA Recombinant Antibody (HPAB-0196-WJ) (HPAB-0196-WJ)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, FC, WB, Neut
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- Rabbit Anti-BTLA Recombinant Antibody (VS-0723-WK222) (VS-0723-WK222)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, FC
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- Mouse Anti-BTLA Recombinant Antibody (HPAB-0194-WJ) (HPAB-0194-WJ)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, FC, WB, Neut, SPR
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- Human Anti-BTLA Recombinant Antibody (HPAB-1605LY) (HPAB-1605LY)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG
- Application: ELISA, FC
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- Mouse Anti-BTLA Recombinant Antibody (HPAB-M0448-YC) (HPAB-M0448-YC)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: FC
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- Mouse Anti-BTLA Recombinant Antibody (HPAB-0195-WJ) (HPAB-0195-WJ)
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- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: ELISA, FC, WB, Neut, SPR
Compare
- Mouse Anti-BTLA Recombinant Antibody (clone HMBT-6B2) (FAMAB-1593CQ)
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- Species Reactivity: Mouse
- Type: Mouse IgG2a
- Application: Block, FuncS, IB, IP, WB, FC
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- Mouse Anti-BTLA Recombinant Antibody; Fab Fragment (HPAB-0196-WJ-F(E)) (HPAB-0196-WJ-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC, WB, Neut
Compare
- Mouse Anti-BTLA Recombinant Antibody; Fab Fragment (HPAB-M0448-YC-F(E)) (HPAB-M0448-YC-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: FC
Compare
- Mouse Anti-BTLA Recombinant Antibody; Fab Fragment (HPAB-0195-WJ-F(E)) (HPAB-0195-WJ-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC, WB, Neut
Compare
- Mouse Anti-BTLA Recombinant Antibody; scFv Fragment (HPAB-0195-WJ-S(P)) (HPAB-0195-WJ-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC, WB, Neut
Compare
- Human Anti-BTLA Recombinant Antibody; Fab Fragment (HPAB-1605LY-F(E)) (HPAB-1605LY-F(E))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, FC
Compare
- Mouse Anti-BTLA Recombinant Antibody; scFv Fragment (HPAB-M0448-YC-S(P)) (HPAB-M0448-YC-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: FC
Compare
- Mouse Anti-BTLA Recombinant Antibody; Fab Fragment (HPAB-0194-WJ-F(E)) (HPAB-0194-WJ-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC, WB, Neut
Compare
- Human Anti-BTLA Recombinant Antibody; scFv Fragment (HPAB-1605LY-S(P)) (HPAB-1605LY-S(P))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scfv
- Application: ELISA, FC
Compare
- Mouse Anti-BTLA Recombinant Antibody; scFv Fragment (HPAB-0194-WJ-S(P)) (HPAB-0194-WJ-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC, WB, Neut
Compare
- Mouse Anti-BTLA Recombinant Antibody; scFv Fragment (HPAB-0196-WJ-S(P)) (HPAB-0196-WJ-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC, WB, Neut
Compare
More Infomation
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