Anti-C1QA Products

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For Research Use Only. Not For Clinical Use.

As a leading immunology and neuroscience research provider, Creative Biolabs offers premium anti-C1QA recombinant antibodies. C1q, as the recognition molecule of the classical complement cascade, is a key initiator of inflammation and is also a key player in synaptic pruning. With high quality antibodies, you can explore the mechanisms and therapies for autoimmune diseases like lupus or dive into cutting edge neurodegeneration research into Alzheimer’s disease.

C1QA: The Initiator of the Classical Complement Pathway

C1q is a large, pentameric molecule built from 3 separate chains (C1QA, C1QB, C1QC) that form the “head” of the C1 complement complex. It functions as a molecular sentinel. C1q directly binds to the Fc portions of antibodies (IgM and IgG) that are “decorating” a target (think bacterium or, in the case of autoimmune disease, a self-cell). When this occurs, a conformational change in C1q “activates” the two proteases bound to the C1 complex (C1r and C1s) and the classical complement cascade is set on fire. C1q has a unique and antibody-independent function in the brain where it is used to “tag” weak or unwanted synapses for removal by microglia, a process which is dysregulated in neurodegeneration.

Alternative Names

C1QD1

Background

This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the A-chain polypeptide of human complement subcomponent C1q.

Anti-C1QA rAb Products

Creative Biolabs’ anti-C1QA recombinant antibodies are developed with high affinity and specificity. We provide antibodies that can be used to recognize the whole C1q complex as well as antibodies to the individual chains. Our antibodies have been optimized for ELISA for measuring C1q levels in plasma (as in lupus, they are depleted) as well as for IHC to visualize C1q deposition in diseased tissues (kidney in lupus nephritis, on synapses in Alzheimer’s brain), making our rAbs premier research tools.

Table 1. Featured anti-C1QA recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs leverages industry leading, state-of-the-art production platforms to rapidly deliver your antibodies for immunology and neuroscience research. The anti-C1QA recombinant antibodies are expressed in optimized systems to ensure that this complex hexameric protein is correctly assembled and recognized, providing you with functional activity that’s second to none.

Featured Anti-C1QA Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-C1QA recombinant antibody production.

Fig.2 Gram-scale anti-C1QA recombinant antibody production.

rAb Modalities

Creative Biolabs’ is committed to providing researchers with flexible and innovative solutions. Our anti-C1QA recombinant antibodies can be found in a variety of modalities that can be customized to your needs including potent functional blocking clones, so that scientists around the globe can explore this important pathway.

Fig.3 Full-length anti-C1QA recombinant antibody production and modalities.

C1QA-Targeted Drug Information

Table 2. Public drug targeting C1QA.

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)
Explore this critical pathway in autoimmunity and neurodegeneration with the precision of Creative Biolabs’ recombinant antibodies. Validated for functional activity and rigorously tested for quality in house, these are the ideal tools to dive into your exploration of this key target. Partner with us for antibodies you can trust. Talk to our experts today.