Recombinant Anti-C1QA Eliminating Antibody, pH-Sensitive (VS-0625-YC33)
CAT#: VS-0625-YC33
The anti-C1QA eliminating antibody is an engineered pH-sensitive antibody against human C1QA. C1QA is a component of the complement system, with deficiencies linked to lupus and glomerulonephritis. The antibody has a novel C1QA-sweeping activity in vivo, which selectively eliminatesthe soluble C1QA from plasma. Compared to conventional antibody, the mAb exerted in vivo efficacy by simultaneously engineering both pH-dependent antigen binding, to mimic the pH-dependent receptor-ligand binding of such endocytic receptors, and increased FcRn binding affinity at neutral pH, to mimic the cell-bound form of the receptors.
Gene Expression
Normal Tissue
Figure 1 Duodenum
Enterocytes
Staining: Medium
Intensity: Strong
Quantity: <25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2350/7234_A_7_2.jpg
Normal Tissue
Figure 2 Colon
Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2350/7234_A_9_3.jpg
Normal Tissue
Figure 3 Lymph node
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2350/7234_A_7_8.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (HMC-1, NB-4, RPMI-8226, SCLC-21H)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000173372-C1QA
❮
❯
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human C1QA
- Species Reactivity
- Human
- Applications
- Antigen-Sweeping In Vivo.
Product Property
- Purification
- Protein A/G purified
- Purity
- >95%
- Format
- Liquid
- Buffer
- PBS only
- Preservative
- None
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "C1QA"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1111z | Mouse Anti-C1QA Recombinant Antibody (clone 41C10) | WB, FC, ICC, IF, IHC, FuncS | Mouse IgG2b |
| MOR-0007-FY | Mouse Anti-C1QA Recombinant Antibody (clone JL-1) | FuncS, IA, IF, WB | Mouse IgG2b |
| VS3-WK134 | Mouse Anti-C1QA Recombinant Antibody (clone G3-C7) | WB, ELISA | Mouse IgG2b |
| VS3-FY173 | Recombinant Mouse Anti-C1QA Antibody (clone 1C9G9) | ELISA, FC | Mouse IgG2b |
| VS3-XY3282 | Rabbit Anti-C1QA Recombinant Antibody (clone R29-1P-7) | WB, IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0403 | Hi-Affi™ Rabbit Anti-C1QA Recombinant Antibody (clone DS403AB) | ICC, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-012CN | Mouse Anti-C1QA Recombinant Antibody (NS-012CN) | ELISA, Neut | Mouse IgG |
| NS-012CN-F(E) | Mouse Anti-C1QA Recombinant Antibody; Fab Fragment (NS-012CN-F(E)) | ELISA | Mouse Fab |
| NS-012CN-S(P) | Mouse Anti-C1QA Recombinant Antibody; scFv Fragment (NS-012CN-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY277 | Anti-C1QA Immunohistochemistry Kit | IHC | |
| VS-0525-XY869 | Anti-Mouse C1QA Immunohistochemistry Kit | IHC | |
| VS-0525-XY870 | Anti-Rat C1QA Immunohistochemistry Kit | IHC | |
| VS-0525-XY868 | Anti-Human C1QA Immunohistochemistry Kit | IHC |
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