Anti-C4A Products

Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us

For Research Use Only. Not For Clinical Use.

Discover the neuroscience and immunology applications of highly specific anti-C4A recombinant antibodies from Creative Biolabs. Complement C4A, one of two isoforms of Complement C4 that is a part of the classical complement pathway, has recently been identified as a major genetic risk factor for schizophrenia. We provide top-quality, isoform-specific antibodies that can be used to explore its role in synaptic pruning and autoimmune disease.

C4A: A Key Complement Component Linked to Schizophrenia

Complement C4 has two highly polymorphic isoforms, C4A and C4B, and is part of the classical/lectin pathway C3 convertase. Following cleavage by classical/lectin pathway C1/MBL-associated serine proteases, C4A and C4B both form a C4a fragment and a C4b fragment. While C4b from both isoforms is responsible for binding to complement-coated proteins, C4A has a higher specificity for binding to amino groups on proteins. Recently, it was discovered that complex genetic variation and copy number increases in the C4A isoform are the single largest genetic risk factor for schizophrenia. The mechanism is thought to be through C4A mediating increased pruning (loss of connections) of synapses by microglia in the developing brain.

Alternative Names

C4; RG; C4S; CO4; C4A2; C4A3; C4A4; C4A6; C4AD; CPAMD2; complement C4-A; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2; C4A anaphylatoxin; MHC class III region complement; Rodgers form of C4; acidic C4; acidic complement C4; complement component 4A (Rodgers blood group)

Background

This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain is cleaved to release C4 anaphylatoxin, an antimicrobial peptide and a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene.

Anti-C4A rAb Products

Our anti-C4A recombinant antibodies are designed for unparalleled isoform specificity. These antibodies are extensively validated to specifically detect the C4A protein without cross-reacting with the highly homologous C4B isoform. Tailored for IHC studies on C4A deposition in the brain as well as for the development of specific ELISAs, our rAbs will provide the performance and reliability you expect from Creative Biolabs.
Table 1. Featured anti-C4A recombinant antibody products at Creative Biolabs.

Creative Quality Control

We have zero tolerance for scientific error at Creative Biolabs. Our anti-C4A recombinant antibodies are produced under a strict quality control system where every lot is tested for purity, as well as isoform specificity against C4B. This way, you can be confident that you will always receive the highest quality reagent.

Fig.1 IHC-P analysis of anti-C4A antibody (Cat# ZG-0303U, Creative Biolabs).

Customer Reviews

rAb Production

Creative Biolabs is proud to serve the highly-specialized scientific community in the field of neuroscience. Our anti-C4A recombinant antibodies are expressed in optimized systems using production platforms that are designed to ensure that our antibodies reliably recognize this important isoform and provide a highly specific and active tool for your experiments.

Featured Anti-C4A Recombinant Antibody Production Platforms
Fig.2 Milligram-scale anti-C4A recombinant antibody production.

Fig.3 Gram-scale anti-C4A recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to fueling scientific breakthroughs and that starts with providing you with flexible, easy-to-use antibody solutions. Our anti-C4A recombinant antibodies are available in a variety of modalities to meet the needs of your experiments and give researchers around the world the tools they need to study this disease-linked protein.

Fig.4 Full-length anti-C4A recombinant antibody production and modalities.

Probe the mechanism of synaptic pruning and schizophrenia with highly specific recombinant antibodies to C4A from Creative Biolabs. Our extensive validation and selection for isoform specificity will give you the tools you need to study this major genetic risk factor. Let us be your partner in neuroscience and immunology research and provide the strong foundation your science deserves. Contact our scientists today.