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C6

This gene encodes a component of the complement cascade. The encoded protein is part of the membrane attack complex that can be incorporated into the cell membrane and cause cell lysis.
Protein class

Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Transporters

Predicted location

Secreted

Single cell type specificity

Cell type enhanced (Hepatocytes, Cholangiocytes, Leydig cells, Respiratory ciliated cells, Late spermatids)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (ASC diff, ASC TERT1, HSkMC)

Interaction

Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and 12-14 copies of the pore-forming subunit C9.

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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