Recombinant Anti-C6 Eliminating Antibody, pH-Sensitive (VS-0625-YC39)
CAT#: VS-0625-YC39
The anti-C6 eliminating antibody is an engineered pH-sensitive antibody against human C6. C6 is part of the membrane attack complex in the complement system to cause cell lysis. The antibody has a novel C6-sweeping activity in vivo, which selectively eliminatesthe soluble C6 from plasma. Compared to conventional antibody, the mAb exerted in vivo efficacy by simultaneously engineering both pH-dependent antigen binding, to mimic the pH-dependent receptor-ligand binding of such endocytic receptors, and increased FcRn binding affinity at neutral pH, to mimic the cell-bound form of the receptors.


Specifications
- Host Species
- Rat
- Type
- Rat IgG
- Specificity
- Human C6
- Species Reactivity
- Human
- Applications
- Antigen-Sweeping In Vivo.
Product Property
- Purification
- Protein A/G purified
- Purity
- >95%
- Format
- Liquid
- Buffer
- PBS only
- Preservative
- None
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
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Related Diseases
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
See other products for "C6"
Select a product category from the dropdown menu below to view related products.
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-0283CT | Mouse Anti-C6 Recombinant Antibody (clone 24I6) | ELISA, IP, WB | Mouse IgG2b |
HPAB-635-FY | Rat Anti-C6 Recombinant Antibody (HPAB-635-FY) | Inhib, SPR, Block | Rat IgG |
HPAB-636-FY | Human Anti-C6 Recombinant Antibody (HPAB-636-FY) | SPR | Humanized IgG |
HPAB-637-FY | Human Anti-C6 Recombinant Antibody (HPAB-637-FY) | SPR | Humanized IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-635-FY-S(P) | Rat Anti-C6 Recombinant Antibody; scFv Fragment (HPAB-635-FY-S(P)) | ELISA, Block | Rat scFv |
HPAB-636-FY-S(P) | Human Anti-C6 Recombinant Antibody; scFv Fragment (HPAB-636-FY-S(P)) | ELISA | Humanized scFv |
HPAB-637-FY-S(P) | Human Anti-C6 Recombinant Antibody; scFv Fragment (HPAB-637-FY-S(P)) | ELISA | Humanized scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-635-FY-F(E) | Rat Anti-C6 Recombinant Antibody; Fab Fragment (HPAB-635-FY-F(E)) | ELISA, Block | Rat Fab |
HPAB-636-FY-F(E) | Human Anti-C6 Recombinant Antibody; Fab Fragment (HPAB-636-FY-F(E)) | ELISA | Humanized Fab |
HPAB-637-FY-F(E) | Human Anti-C6 Recombinant Antibody; Fab Fragment (HPAB-637-FY-F(E)) | ELISA | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0525-XY892 | Anti-Rat C6 Immunohistochemistry Kit | IHC |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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