Disease related genes, Human disease related genes
Intracellular
Cell type enhanced (Langerhans cells)
Group enriched (intermediate monocyte, non-classical monocyte, neutrophil, classical monocyte, myeloid DC, basophil)
Low cell line specificity
Component of the C9orf72-SMCR8 complex, at least composed of C9orf72, SMCR8 and WDR41 (PubMed:27193190, 27103069, 27559131, 27617292, 28195531, 32303654). The complex is formed of two protomers, each individually consisting of one molecule each of C9orf72, SMCR8 and WDR41 (PubMed:32303654). The protomers homodimerize via an interaction between C9orf72 (via C-terminus) and SMCR8 (via N-terminus) (PubMed:32303654). Within each protomer SMCR8 (via DENN domain) acts as a bridging protein between WDR41 (via C-terminus and N-terminus) and C9orf72 (via C-terminus) (PubMed:32303654). The C9orf72-SMCR8 complex associates with the ULK1/ATG1 kinase complex (PubMed:27617292, 28195531). Interacts with ULK1/ATG1 kinase complex members ULK1, ATG13 and RB1CC1 (PubMed:27334615). Interacts with SMCR8; the interaction is direct (PubMed:27559131, 27617292, 32303654). Interacts with HNRNPA1, HNRNPA2B1 and UBQLN2 (PubMed:24549040). Interacts with small Rab GTPase RAB1A; the interaction mediates recruitment of RAB1A to the ULK1/ATG1 kinase complex (PubMed:27334615). Also interacts with small Rab GTPase RAB7A (By similarity). Interacts with cofilin (PubMed:27723745). Interacts with GTP-binding proteins ARF1 and ARF6 (By similarity). Interacts with the DLG4/PSD-95 (By similarity). Interacts with CARM1 (via PH domain-like fold) (By similarity).
Guanine-nucleotide releasing factor
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For Research Use Only. Not For Clinical Use.