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Anti-CDH6 Recombinant Antibody Products

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Anti-CDH6 Products

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For Research Use Only. Not For Clinical Use.


Creative Biolabs is proud to offer an extensive selection of cutting-edge recombinant antibodies specifically targeting CDH6, playing a pivotal role in advancing biomedical research and innovation. Utilizing state-of-the-art technologies and sophisticated development platforms, we guarantee that every product adheres to the strictest standards of quality, consistency, and performance. Our commitment to supporting scientific progress is reflected in the wide array of recombinant solutions we provide, all carefully designed to deliver outstanding reliability and value. Beyond offering premium-grade antibodies, Creative Biolabs is equally dedicated to delivering exceptional technical support, assisting researchers at every step-from project design to data interpretation. By choosing Creative Biolabs as your partner, you gain not only access to innovative research tools but also the backing of a dependable, forward-thinking collaborator in your scientific endeavors.

CDH6: A Key Target in Cancer Progression and Therapeutic Development

CDH6 (Cadherin 6) is a cell adhesion molecule primarily expressed in kidney tissues, but its role extends to various types of cancer. As a member of the cadherin family, CDH6 is involved in maintaining cellular integrity and communication, which are essential for tissue structure and function. In the context of disease, elevated expression of CDH6 has been associated with several malignancies, including renal cell carcinoma (RCC), where it plays a pivotal role in tumor progression and metastasis. The aberrant overexpression of CDH6 disrupts normal cell adhesion, contributing to cancer cell migration and invasion. Additionally, CDH6 has shown potential as a therapeutic target, with ongoing research exploring its role in cancer diagnostics and treatment. Targeting CDH6 may allow for the development of novel therapies aimed at inhibiting tumor growth and improving patient outcomes. Its selective expression in specific cancer cells also makes it a promising candidate for targeted therapies, minimizing damage to healthy tissues while enhancing the effectiveness of treatments.

Alternative Names

Complement CAD6; KCAD; CDH6

Background

This gene encodes a member of the cadherin superfamily. Cadherins are membrane glycoproteins that mediate homophilic cell-cell adhesion and play critical roles in cell differentiation and morphogenesis. The encoded protein is a type II cadherin and may play a role in kidney development as well as endometrium and placenta formation. Decreased expression of this gene may be associated with tumor growth and metastasis.

Protein class

Plasma proteins

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Proximal tubular cells, Smooth muscle cells, Excitatory neurons, Pancreatic endocrine cells, Oligodendrocyte precursor cells, Cholangiocytes, Sertoli cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enriched (EFO-21)

More Types Infomation

Anti-CDH6 rAb Products

At Creative Biolabs, our core mission is to drive progress in scientific discovery by offering high-performance recombinant antibodies against CDH6. We are dedicated to equipping researchers with not only top-tier, dependable products but also the resources and guidance needed to ensure experimental success. Through a combination of scientific excellence, product reliability, and personalized technical assistance, we aim to empower research initiatives and foster meaningful breakthroughs across a wide range of biomedical fields.

Cat. No. Product Name Target Species Host Species Applications
TAB-405LC Human Anti-CDH6 Recombinant Antibody (TAB-405LC) Human Human ELISA; FC
PABC-397 Human Anti-CDH6 Recombinant Antibody (clone Ab-HKT288) Human Human ELISA; FC
HPAB-0391-FY Human Anti-CDH6 Recombinant Antibody (HPAB-0391-FY) Human; Monkey; Rat; Mouse Human FC; ELISA; Activ
ZG-0979F Mouse Anti-CDH6 Recombinant Antibody (clone 2B6) Human; Rat Mouse ICC; IHC-F; IHC-P; WB
VS-0723-WK69 Human Anti-CDH6 Recombinant Antibody (VS-0723-WK69) Human Human FC

Customer Reviews

Excellent
W**am
Human Anti-CDH6 Recombinant Antibody (VS-0723-WK69)
(CAT#: VS-0723-WK69)
I used this to perform flow cytometry on HEK293T cells transfected with CDH6, The antibody showed good specificity with low background and worked well without much protocol adjustment. Staining was consistent across different experiments. Technical support was helpful when I had a quick question. Overall, a reliable choice for FC applications.
14/Jul/2023
Excellent
M**el
Human Anti-CDH6 Recombinant Antibody (HPAB-0391-FY)
(CAT#: HPAB-0391-FY)
In my ELISA and activation assays using CDH6-expressing HEK293 cells, It produced strong and specific signals.Performance was stable across experiments, with little need for further optimization. A reliable option for these applications.
10/Oct/2023
Excellent
L**on
Human Anti-CDH6 Recombinant Antibody (clone Ab-HKT288)
(CAT#: PABC-397)
During testing on CDH6-overexpressing HEK293 cells, I evaluated it in ELISA and flow cytometry. It showed strong and specific signals in ELISA and clear staining with low background in FC. The antibody was effective at the recommended settings and required minimal optimization. A reliable tool for both applications.
20/May/2024

rAb Production

With years of experience in recombinant antibody development and optimization, we are committed to offering outstanding service. We supply high-quality recombinant antibody products, maintaining strict standards while ensuring fast delivery.

Featured Anti-CDH6 Recombinant Antibody Production PlatformsMilligram-scale recombinant antibody production. (Creative Biolabs Original)
Fig.1 Milligram-scale recombinant antibody production.

Gram-scale recombinant antibody production. (Creative Biolabs Original)Fig.2 Gram-scale recombinant antibody production.

rAb Modalities

Creative Biolabs is dedicated to empowering the research community with an extensive portfolio of cutting-edge recombinant antibodies, available in a range of customizable formats to suit diverse experimental needs. Backed by deep expertise in antibody engineering and molecular design, our team delivers innovative solutions tailored to meet the specific challenges of your research. In addition to our high-performance antibody products, we offer flexible custom services and technical support to help you achieve optimal results at every stage of your project.

Full Length Anti-CDH6 Recombinant Antibody Production and Modalities. (Creative Biolabs Original)Fig.3 Full Length Anti-CDH6 Recombinant Antibody Production and Modalities.

Drug Information Targeting CDH6

Table 1. Therapeutic approaches targeting CDH6 in clinical development.

Research phase Company Classification Indications Details
Phase II/III Daiichi Sankyo Drug Conjugates
Cancer;
Carcinoma, primary peritoneal
Daiichi Sankyo's anti-CDH6 ADC is in late-stage trials for cancer and will be co-developed globally with Merck, excluding Japan.
Phase I Multitude Drug Conjugates Cancer; Solid tumor OnCusp Therapeutics is developing a CDH6-targeting ADC with exatecan for advanced tumors, licensed from Multitude in 2022.
Phase I MorphoSys Drug Conjugates Cancer Novartis was investigating HKT-288, a CDH6-targeting ADC, in early trials for ovarian and renal cancers, but the study was suspended in 2017 and terminated in 2018.

If you need more information about the CDH6 target, please don't hesitate to contact us by phone or email. Our experienced team is ready to help answer any questions or troubleshoot issues you encounter during your experiments, providing the support necessary for your research success.

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