Anti-CUBN Products

Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us

For Research Use Only. Not For Clinical Use.

Creative Biolabs provides top-tier anti-CUBN recombinant antibodies for your nutrition and nephrology research needs. Cubilin (CUBN) is a critical megalin-binding protein and a major absorptive receptor. It is involved in the uptake of vitamin B12 and other important proteins. Our high-quality recombinant antibodies can be useful tools to help you better understand the molecular pathology of pernicious anemia and to study renal protein reabsorption.

CUBN: The Intestinal and Renal Absorptive Receptor

Cubilin, also known as CUBN, is a large peripheral membrane protein that serves as a major absorptive receptor in both the small intestine and kidney proximal tubules. CUBN has no transmembrane domain and is internalized through its co-receptor, Megalin (LRP2). Megalin and Cubilin bind and internalize many important ligands, most notably the Vitamin B12-Intrinsic Factor complex (required for B12 absorption). The CUBN/Megalin complex also reabsorbs filtered proteins from the urine in the kidney and prevents them from being excreted. Mutations in the CUBN gene lead to Imerslund-Gräsbeck syndrome, an inherited disease that causes vitamin B12 deficiency and proteinuria.

Alternative Names

IGS; IFCR; IGS1; MGA1; gp280

Background

Cubilin (CUBN) acts as a receptor for intrinsic factor-vitamin B12 complexes. The role of receptor is supported by the presence of 27 CUB domains. Cubulin is located within the epithelium of intestine and kidney. Mutations in CUBN may play a role in autosomal recessive megaloblastic anemia.

Anti-CUBN rAb Products

Our anti-CUBN recombinant antibodies are designed with a high degree of specificity and optimized for best performance. They are thoroughly validated and will accurately detect the Cubilin protein. Engineered for use in applications such as IHC on intestinal and kidney sections, and Western Blot, our rAbs deliver the specificity and reliability you need to further your research into the mechanisms of nutrient and protein transport.

Table 1. Featured anti-CUBN recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs is committed to your research and is constantly pushing the boundaries of antibody production technologies. Our anti-CUBN recombinant antibodies are expressed in systems that have been optimized to ensure they will specifically recognize the native protein, so you can be confident you are receiving a specific and active research tool for your experiments.

Featured Anti-CUBN Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CUBN recombinant antibody production.

Fig.2 Gram-scale anti-CUBN recombinant antibody production.

rAb Modalities

Creative Biolabs empowers scientific discovery by offering a variety of flexible antibody solutions. Our anti-CUBN recombinant antibodies are available in a variety of customizable modalities to fit the needs of your experiments, so researchers from around the world can better study this important absorptive receptor.

Fig.3 Full-length anti-CUBN recombinant antibody production and modalities.

Gain new insights into the important role of Cubilin in nutrient uptake with Creative Biolabs recombinant antibodies. Defined by their high specificity and rigorous validation, our portfolio offers the best tools for your research needs into B12 deficiency and kidney disease. Choose quality that leads to discovery. Contact our experts today.