Rabbit Anti-CUBN Recombinant Antibody (clone R09-5I6) (CAT#: VS3-XY3328)
This product is a recombinant rabbit antibody targeting the CUBN (Cubilin), which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake. It recognizes and binds to human CUBN. It also has cross-reactivity against mouse and rat CUBN. It has been determined using Western Blot. The recommended dilutions of Western Blot is 1/500-1/1000.
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Normal Tissue
RNA Expression
Figure 1 High expression in kidney
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4133/ihc_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4133/ihc_selected.jpg
Figure 2 Low expression in lymph node
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4133/150446_A_8_8_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4133/150446_A_8_8_val_selected.jpg
Figure 3 Low expression in pancreas
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43854/150450_A_1_3_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43854/150450_A_1_3_val_selected.jpg
Figure 4 Small intestine
(Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43854/150450_A_6_2.jpg
(Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43854/150450_A_6_2.jpg
Figure 5 Kidney
(Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43854/150450_A_7_5.jpg
(Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43854/150450_A_7_5.jpg
Figure 6 RNA cell line category: Cell line enhanced (AN3-CA, ASC TERT1, SK-MEL-30, WM-115)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000107611-CUBN
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000107611-CUBN
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat CUBN
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R09-5I6
- Applications
- WB
- Related Disease
- Imerslund-Grasbeck Syndrome 1; Proteinuria, Chronic Benign
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
Target
- Alternative Names
- IGS; IFCR; IGS1; MGA1; gp280
- Gene ID
- 8029
- UniProt ID
- O60494
- Long Name
- Cubilin
- Cellular Localization
- Cell membrane, Endosome
- Post Translation Modifications
- N-glycosylated. (O60494-CUBN_HUMAN)
Glycosylation at Asn105, Asn428, Asn482, Asn711, Asn749, Asn781, Asn857, Asn957, Asn984, Asn1092, Asn1168, Asn1217, Asn1285, Asn1307, Asn1319, Asn1332, Asn1500, Asn1551, Asn1646, Asn1802, Asn1819, Asn1885, Asn2085, Asn2117, Asn2274, Asn2386, Asn2400, Asn2531, Asn2581, Asn2592, Asn2610, Asn2813, Asn2923, Asn2945, Asn3042, Asn3103, Asn3125, Asn3165, Asn3268, Asn3283, Asn3290, Asn3295, Asn3357, Asn3430, Asn3457, Asn3533, and Asn3576 (NX_O60494 [NX_O60494-1])
Modification sites at PhosphoSitePlus (O60494)
Glycosylation from GlyConnect CUBN_HUMAN (2033)
Glycosylation from GlyGen (O60494) 54 sites, 3 N-linked glycans (2 sites), 3 O-linked glycans (6 sites)
- Protein Refseq
- XP_011518010.1; XP_011518011.1
- Function
- Acts together with LRP2 to mediate endocytosis of high-density lipoproteins, GC, hemoglobin, ALB, TF and SCGB1A1. Acts together with AMN to mediate endocytosis of the CBLIF-cobalamin complex
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1811z-F(E) | Recombinant Anti-Human CUBN Antibody Fab Fragment | ELISA, FuncS | Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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