Rabbit Anti-CUBN Recombinant Antibody (clone R09-5I6)
CAT#: VS3-XY3328
This product is a recombinant rabbit antibody targeting the CUBN (Cubilin), which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake. It recognizes and binds to human CUBN. It also has cross-reactivity against mouse and rat CUBN. It has been determined using Western Blot. The recommended dilutions of Western Blot is 1/500-1/1000.
Gene Expression
Normal Tissue
Figure 1 High expression in kidney
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4133/ihc_selected.jpg
Normal Tissue
Figure 2 Low expression in lymph node
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4133/150446_A_8_8_val_selected.jpg
Normal Tissue
Figure 3 Low expression in pancreas
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43854/150450_A_1_3_val_selected.jpg
Normal Tissue
Figure 4 Small intestine
Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43854/150450_A_6_2.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43854/150450_A_7_5.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (AN3-CA, ASC TERT1, SK-MEL-30, WM-115)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000107611-CUBN
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat CUBN
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R09-5I6
- Applications
- WB
- Related Disease
- Imerslund-Grasbeck Syndrome 1; Proteinuria, Chronic Benign
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
Target
- Alternative Names
- IGS; IFCR; IGS1; MGA1; gp280
- Gene ID
- 8029
- UniProt ID
- O60494
- Long Name
- Cubilin
- Cellular Localization
- Cell membrane, Endosome
- Post Translation Modifications
- N-glycosylated. (O60494-CUBN_HUMAN)
Glycosylation at Asn105, Asn428, Asn482, Asn711, Asn749, Asn781, Asn857, Asn957, Asn984, Asn1092, Asn1168, Asn1217, Asn1285, Asn1307, Asn1319, Asn1332, Asn1500, Asn1551, Asn1646, Asn1802, Asn1819, Asn1885, Asn2085, Asn2117, Asn2274, Asn2386, Asn2400, Asn2531, Asn2581, Asn2592, Asn2610, Asn2813, Asn2923, Asn2945, Asn3042, Asn3103, Asn3125, Asn3165, Asn3268, Asn3283, Asn3290, Asn3295, Asn3357, Asn3430, Asn3457, Asn3533, and Asn3576 (NX_O60494 [NX_O60494-1])
Modification sites at PhosphoSitePlus (O60494)
Glycosylation from GlyConnect CUBN_HUMAN (2033)
Glycosylation from GlyGen (O60494) 54 sites, 3 N-linked glycans (2 sites), 3 O-linked glycans (6 sites)
- Protein Refseq
- XP_011518010.1; XP_011518011.1
- Function
- Acts together with LRP2 to mediate endocytosis of high-density lipoproteins, GC, hemoglobin, ALB, TF and SCGB1A1. Acts together with AMN to mediate endocytosis of the CBLIF-cobalamin complex
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "CUBN"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1811z-F(E) | Recombinant Anti-Human CUBN Antibody Fab Fragment | ELISA, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1811z-S(P) | Recombinant Anti-Human CUBN Antibody scFv Fragment | FC, Neut, Biosensors, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-0401-CN | Rabbit Anti-CUBN Recombinant Antibody (clone JB42-13) | WB, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1795 | Anti-CUBN Immunohistochemistry Kit | IHC |
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