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CXCL10

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Anti-CXCL10 Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


Predicted to enable chemoattractant activity; chemokine receptor binding activity; and heparin binding activity. Involved in cellular response to interleukin-17. Acts upstream of or within several processes, including defense response to virus; negative regulation of myoblast differentiation; and negative regulation of myoblast fusion. Located in external side of plasma membrane and extracellular space. Is expressed in several structures, including alimentary system; axial skeleton; hemolymphoid system; lacrimal gland; and liver. Human ortholog(s) of this gene implicated in hepatitis B; middle cerebral artery infarction; and type 1 diabetes mellitus.
CXCL10
Protein class

Cancer-related genes, Human disease related genes, Plasma proteins

Predicted location

Secreted

Single cell type specificity

Cell type enhanced (Basal respiratory cells, Macrophages, Kupffer cells, Glandular and luminal cells, Plasma cells, Langerhans cells)

Immune cell specificity

Group enriched (intermediate monocyte, non-classical monocyte, classical monocyte)

Cell line specificity

Cell line enhanced (BJ hTERT+, BJ hTERT+ SV40 Large T+, BJ hTERT+ SV40 Large T+ RasG12V, GAMG, RPMI-8226, RT4, THP-1)

Interaction

Monomer, dimer, and tetramer (PubMed:12737818). Interacts with CXCR3 (via N-terminus) (PubMed:19151743).

Molecular function

Cytokine

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Related Signaling Pathways
TNF Signaling Pathway TNF Signaling Pathway
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