Human Anti-CXCL10 scFv-Fc Chimera (VS-0425-FY99)
CAT#: VS-0425-FY99
This scFv-Fc fusion protein targets CXCL10 (IP-10), an interferon-inducible chemokine involved in immune cell recruitment and inflammation. By neutralizing CXCL10, it can reduce inflammation and immune cell infiltration, offering potential therapeutic benefits in autoimmune and inflammatory diseases.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (BJ hTERT+, BJ hTERT+ SV40 Large T+, BJ hTERT+ SV40 Large T+ RasG12V, GAMG, RPMI-8226, RT4, THP-1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000169245-CXCL10
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Specifications
- Immunogen
- Human CXCL10 as an immunogen.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human CXCL10
- Species Reactivity
- Human
- Applications
- ELISA
- Related Disease
- Autoimmune disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- C-X-C Motif Chemokine Ligand 10; Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 10; 10 KDa Interferon Gamma-Induced Protein; Chemokine (C-X-C Motif) Ligand 10; Small-Inducible Cytokine B10; SCYB10; INP10; IP-10; Protein 10 From Interferon (Gamma)-Induced Cell Line; Interferon-Inducible Cytokine IP-10
- Gene ID
- 3627
- UniProt ID
- P02778
- Long Name
- C-X-C Motif Chemokine Ligand 10
- Sequence Similarities
- Belongs to the intercrine alpha (chemokine CxC) family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Several proteases can mediate post-secretion cleavages.
DPP4 cleaves CXCL10 on its N-terminal 2 amino acids leading to an antagonist form of CXCL10.
This dominant negative form is capable of binding CXCR3 but does not induce signaling.
MMP9 cleaves 9 amino acids instead.
Modification sites at PhosphoSitePlus
Modification sites at neXtProt
- Protein Refseq
- NP_001556.2
- Function
- Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects.
Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites.
Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization.
In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation.
Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site.
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Related Signaling Pathways
TNF Signaling Pathway
Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| MOR-0882 | Hi-Affi™ Rabbit Anti-CXCL10 Recombinant Antibody (clone DS882AB) | WB | Rabbit IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0152CQ-F(E) | Human Anti-CXCL10 Recombinant Antibody; Fab Fragment (HPAB-0152CQ-F(E)) | ELISA, WB, FC, Inhib | Human Fab |
| HPAB-0153CQ-F(E) | Human Anti-CXCL10 Recombinant Antibody; Fab Fragment (HPAB-0153CQ-F(E)) | ELISA, WB, FC, Inhib | Human Fab |
| HPAB-1676-FY-S(P) | Human Anti-CXCL10 Recombinant Antibody; scFv Fragment (HPAB-1676-FY-S(P)) | Inhib, ELISA, FC | Human scFv |
| HPAB-1677-FY-S(P) | Human Anti-CXCL10 Recombinant Antibody; scFv Fragment (HPAB-1677-FY-S(P)) | Inhib, ELISA, FC | Human scFv |
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| AFC-TAB-742 | Afuco™ Anti-CXCL10 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-742) | IP, IF, FuncS, FC, Neut, ELISA | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP613-YC-S(P) | Human Anti-CXCL10 Recombinant Antibody (clone 9E); scFv Fragment | ELISA | Human scFv |
| HPAB-AP614-YC-S(P) | Human Anti-CXCL10 Recombinant Antibody (clone 10E); scFv Fragment | ELISA, WB, Inhib | Human scFv |
| HPAB-AP615-YC-S(P) | Human Anti-CXCL10 Recombinant Antibody (clone 10D); scFv Fragment | ELISA, WB, Inhib | Human scFv |
| HPAB-AP616-YC-S(P) | Human Anti-CXCL10 Recombinant Antibody (clone 12D); scFv Fragment | ELISA | Human scFv |
| HPAB-AP617-YC-S(P) | Human Anti-Cxcl10 Recombinant Antibody (clone 2A); scFv Fragment | ELISA, Inhib, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| HPAB-1679-FY | Mouse Anti-CXCL10 Recombinant Antibody (clone AIP13) | ELISA, Block | Mouse IgG2b, κ |
| HPAB-1680-FY | Human Anti-CXCL10 Recombinant Antibody (clone HuAIP13) | ELISA | Human IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY95 | CytoStream™ Mouse Anti-CXCL10 Recombinant Antibody (VS-0225-XY95) | FC | Mouse IgG2a, kappa |
| VS13-YC276 | CytoStream™ Rabbit Anti-Cxcl10 Polyclonal Antibody (VS13-YC276) | ELISA, IHC-P, IHC-Fr, FC, ICC, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
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| VS-0325-XY591 | Anti-CXCL10 Immunohistochemistry Kit | IHC | |
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