Human Anti-CXCL10 scFv-Fc Chimera (VS-0425-FY99) (CAT#: VS-0425-FY99)

• Immunogen
• Human CXCL10 as an immunogen.

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Specificity
• Human CXCL10

• Species Reactivity
• Human

• Applications
• ELISA

• Related Disease
• Autoimmune disease

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• The optimal dilution concentration is determined by the experiment.

• Alternative Names
• C-X-C Motif Chemokine Ligand 10; Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 10; 10 KDa Interferon Gamma-Induced Protein; Chemokine (C-X-C Motif) Ligand 10; Small-Inducible Cytokine B10; SCYB10; INP10; IP-10; Protein 10 From Interferon (Gamma)-Induced Cell Line; Interferon-Inducible Cytokine IP-10

• Gene ID
• 3627

• UniProt ID
• P02778

• Long Name
• C-X-C Motif Chemokine Ligand 10

• Sequence Similarities
• Belongs to the intercrine alpha (chemokine CxC) family.

• Cellular Localization
• Secreted

• Post Translation Modifications
• Several proteases can mediate post-secretion cleavages.
  DPP4 cleaves CXCL10 on its N-terminal 2 amino acids leading to an antagonist form of CXCL10.
  This dominant negative form is capable of binding CXCR3 but does not induce signaling.
  MMP9 cleaves 9 amino acids instead.
  Modification sites at PhosphoSitePlus
  Modification sites at neXtProt

• Protein Refseq
• NP_001556.2

• Function
• Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects.
  Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites.
  Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization.
  In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation.
  Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site.

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