Anti-CXCR1 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is a global provider of inflammation and oncology research reagents, offering world-class anti-CXCR1 recombinant antibodies. CXCR1 is the high-affinity receptor for the neutrophil chemoattractant CXCL8 (IL-8), and is a key driver of acute inflammation. These best-in-class antibodies have applications in the study of neutrophil recruitment, anti-inflammatory drug discovery, and the role of IL-8 signaling in cancer.

CXCR1: The High-Affinity Receptor for Neutrophil Recruitment

C-X-C Motif Chemokine Receptor 1 (CXCR1), also known as IL-8 Receptor Alpha, is a G protein-coupled receptor (GPCR) that is highly expressed on neutrophils. CXCR1 has high affinity for its ligand, CXCL8 (IL-8). The signal mediated by this interaction is the primary mechanism by which neutrophils are recruited from circulation to the site of acute infection or inflammation. Rapid migration of neutrophils into tissue is the defining feature of acute inflammation. Prolonged or aberrant signaling through CXCR1 can also lead to tissue damage in chronic inflammatory diseases, and IL-8/CXCR1 signaling is known to be a pro-survival and pro-angiogenic pathway in many cancers.

Alternative Names

CXCR1; Human CXCR1

Background

CXCR1 (C-X-C Motif Chemokine Receptor 1) is a Protein Coding gene. Diseases associated with CXCR1 include Human Immunodeficiency Virus Type 1 and Acute Pyelonephritis. Among its related pathways are Akt Signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and interleukin-8 binding. An important paralog of this gene is CXCR2.

Anti-CXCR1 rAb Products

Creative Biolabs' anti-CXCR1 recombinant antibodies are designed for superior specificity and robust functional activity. They are validated for robust detection of CXCR1 on the surface of primary human neutrophils. Optimized for demanding applications including multi-color flow cytometry, functional blocking of chemotaxis, and IHC, our rAbs are the tools of choice for drug discovery and immunology.

Table 1. Featured anti-CXCR1 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs is leveraging next generation production technologies to help speed drug discovery research. Our anti-CXCR1 recombinant antibodies are engineered to recognize the native conformation of the extracellular domains of the receptor, ensuring high functional activity.

Featured Anti-CXCR1 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CXCR1 recombinant antibody production.

Fig.2 Gram-scale anti-CXCR1 recombinant antibody production.

rAb Modalities

Creative Biolabs is dedicated to offering next generation tools with complete flexibility to the research community. Our anti-CXCR1 recombinant antibodies are available in many customizable modalities, including functional blocking clones and conjugated formats, to help researchers around the globe study this important receptor.

Fig.3 Full-length anti-CXCR1 recombinant antibody production and modalities.

CXCR1-Targeted Drug Information

Table 2. Public drug targeting CXCR1.

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

Drive your research in inflammation and oncology with Creative Biolabs' high quality anti-CXCR1 recombinant antibodies. Our portfolio is designed to offer the highest specificity and robust functional validation, making these the ideal tools for studying neutrophil recruitment and IL-8 signaling. We are here to support your critical work with best-in-class antibodies, so contact our specialists today.