CyRPA
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Loading...- Recombinant Mouse Anti-CyRPA Antibody (8A7) (PABC-476)
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- Species Reactivity: P. falciparum
- Type: Mouse IgG1, κ
- Application: IB, Inhib, ELISA, WB
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- Recombinant Chicken Anti-CyRPA Antibody (clone Cy.004) (VS-0923-XY5)
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- Species Reactivity: P. falciparum
- Type: Chicken IgY
- Application: ELISA, SPR, Inhib
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- Recombinant Mouse Anti-CyRPA Antibody (clone Cy.002) (VS-0923-XY6)
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- Derivation: Hybridoma
- Species Reactivity: P. falciparum
- Type: Mouse IgG
- Application: ELISA, SPR
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For Research Use Only. Not For Clinical Use.
Background
The leading vaccine candidates for a P. falciparum blood-stage malaria vaccine are members of a heterotrimeric complex containing reticulocyte-binding protein homolog 5 (RH5), cysteinerich protective antigen (CyRPA), and RH5-interacting protein (RIPR), collectively called the "RCR complex"15. Each member of this complex is highly conserved, essential for erythrocyte invasion, and capable of inducing cross-strain neutralizing antibodies. The leading blood-stage malaria vaccine candidate, CyRPA, is essential for invasion of Plasmodium falciparum into human erythrocytes.