EGFR & FcγRI

EGFR encodes a receptor tyrosine kinase that is involved in the regulation of cell growth, survival, and differentiation. It is activated by binding to its ligands, such as epidermal growth factor (EGF), and mediates downstream signaling pathways that control cellular processes like proliferation, migration, and differentiation. EGFR is critical in normal development, wound healing, and tissue repair. However, mutations or overexpression of EGFR are associated with various cancers, including non-small cell lung cancer (NSCLC), making EGFR a target for cancer therapies, including monoclonal antibodies and tyrosine kinase inhibitors.

This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1.