Anti-ENO2 Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is a global leader in neuro-oncology diagnostics and high-impact research, offering elite anti-ENO2 (NSE) recombinant antibodies to the scientific community. As a classic and highly specific marker for neurons and various neuroendocrine tumors, ENO2 is an indispensable tool for diagnostic pathology and the study of brain health. Our high-quality antibodies provide the exceptional specificity and sensitivity required for both fundamental biological research and the development of sensitive clinical diagnostic assays.

ENO2: Neuron-Specific Enolase

ENO2, widely and clinically known as Neuron-Specific Enolase (NSE), is a key glycolytic enzyme that is primarily and highly expressed in mature neurons and neuroendocrine cells. Its unique and highly restricted expression pattern makes it one of the most widely used and reliable immunohistochemical markers in diagnostic pathology. Serum NSE levels are frequently and significantly elevated in patients with various neuroendocrine tumors, such as small cell lung cancer (SCLC) and neuroblastoma. It is also used as a sensitive marker for assessing the extent of neuronal damage following traumatic brain injury or cardiac arrest.

Alternative Names

Enolase 2; 2-Phospho-D-Glycerate Hydro-Lyase; Enolase 2 (Gamma, Neuronal); Neuronal Enriched Enolase; Neuron-Specific Enolase; Neural Enolase; Gamma-Enolase; EC 4.2.1.11;

Background

This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. This gene encodes one of three enolase isoenzymes found in mammals. This isoenzyme is a homodimer and is found in mature neurons and cells of neuronal origin.

Anti-ENO2 rAb Products

Our anti-ENO2 recombinant antibodies are specifically engineered for outstanding specificity, clearly distinguishing NSE from the other highly homologous enolase isoforms (alpha and gamma). They are meticulously and independently validated for high-performance applications like IHC, Western Blotting, and sensitive sandwich ELISA. These rAbs are premier tools for accurately identifying neuroendocrine lineages in tumor biopsies and for the precise quantification of neuronal injury markers in biological fluids, ensuring reliable and publication-quality results.

Creative Quality Control

At Creative Biolabs, scientific quality and technical consistency are the cornerstones of our diagnostic-grade reagents. Each lot of our anti-ENO2 antibody is thoroughly tested for purity, absolute isoform specificity, and consistent performance in validated clinical and research models. This extensive commitment to quality assurance ensures that you receive a dependable reagent for your most critical studies, providing the reliable and reproducible data required for translating laboratory findings into improved clinical outcomes.

Customer Reviews

Excellent

Ken**n
Mouse Anti-ENO2 Recombinant Antibody (clone NSE-P1)

This has been a gold-standard marker in our diagnostic pathology lab for several years. The staining for neuroendocrine cells is always exceptionally strong and specific, with zero cross-reactivity issues with other enolase isoforms. It has allowed us to accurately diagnose several challenging cases of small cell lung cancer, and the antibody performance remains highly consistent from batch to batch. We highly recommend this reagent for any high-volume diagnostic or research application.

01/Apr/2024

rAb Production

To support the exceptionally demanding field of clinical diagnostics and neurobiology, Creative Biolabs utilizes advanced production technologies for the generation of all our anti-ENO2 recombinant antibodies. Expressed in high-yield mammalian systems, these rAbs ensure the highest degree of protein folding and high affinity for the native enzyme structure. By maintaining a strictly controlled manufacturing environment, we guarantee the production of a high-purity and functionally active product that will perform consistently and reliably across all your sensitive assays.

Featured Anti-ENO2 Recombinant Antibody Production Platforms
Fig.3 Milligram-scale anti-ENO2 recombinant antibody production.

Fig.4 Gram-scale anti-ENO2 recombinant antibody production.

rAb Modalities

We offer a comprehensive suite of antibody formats, including fully validated matched antibody pairs for sandwich ELISA development and full-length IgGs for high-resolution IHC. Customizable conjugations to a variety of tracers and markers are also available for use on modern automated diagnostic platforms. Our team is dedicated to providing the specific molecular tools required to address the most challenging questions in neuro-oncology and the study of neuronal injury globally.

Fig.5 Full-length anti-ENO2 recombinant antibody production and modalities.

Drive progress in neuro-oncology research and clinical diagnostics with the superior quality and technical excellence of Creative Biolabs' anti-ENO2 recombinant antibodies. Our portfolio offers the high specificity, rigorous validation, and technical consistency required for sensitive biomarker assays and pathological studies. Partner with us to access diagnostic-grade reagents that will enhance the integrity of your data and help you achieve your goals. Contact our specialists today to learn more.