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    ENO2

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    For Research Use Only. Not For Clinical Use.


    This gene encodes one of three enolase isoenzymes found in mammals. This isoenzyme is a homodimer and is found in mature neurons and cells of neuronal origin.
    This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. [provided by RefSeq, Jul 2008]
    Protein class

    Cancer-related genes, Candidate cardiovascular disease genes, Enzymes, Metabolic proteins, Plasma proteins

    Predicted location

    Intracellular

    Single cell type specificity

    Cell type enhanced (Rod photoreceptor cells, Horizontal cells, Bipolar cells, Cone photoreceptor cells)

    Immune cell specificity

    Group enriched (memory CD4 T-cell, memory CD8 T-cell, MAIT T-cell, gdT-cell, naive CD8 T-cell, naive CD4 T-cell, T-reg, neutrophil, memory B-cell, naive B-cell)

    Cell line specificity

    Cell line enhanced (hTERT-RPE1, U-87 MG)

    Interaction

    Mammalian enolase is composed of 3 isozyme subunits, alpha, beta and gamma, which can form homodimers or heterodimers which are cell-type and development-specific.

    Molecular function

    Lyase

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