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FER
Enables protein kinase activity and protein phosphatase 1 binding activity. Involved in several processes, including cell surface receptor signaling pathway; cell-cell adhesion mediated by cadherin; and substrate adhesion-dependent cell spreading. Acts upstream of or within several processes, including cell adhesion; chemotaxis; and protein autophosphorylation. Predicted to be located in cytosol and nucleus. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Predicted to colocalize with several cellular components, including chromatin; cytoskeleton; and lamellipodium. Is expressed in central nervous system and retina. Orthologous to human FER (FER tyrosine kinase).
Protein class
Enzymes, Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Group enriched (Inhibitory neurons, Oligodendrocyte precursor cells, Excitatory neurons, Microglial cells, Oligodendrocytes, Astrocytes, Late spermatids, Early spermatids, granulocytes, Alveolar cells type 1)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enriched (RPMI-8226)
Interaction
Homotrimer. Interacts with ARHGDIA, IRS1, JAK1, NRP1, PIK3R1, PLEC and TMF1. Interacts with PPP1CA and regulates its phosphorylation at 'Thr-320' (By similarity). Interacts with CTNND1, EGFR, FLT3, PECAM1, PDGFR and STAT3. Interacts (via SH2 domain) with CTTN. Interacts with HSP90; this stabilizes phosphorylated FER and protects FER against proteasomal degradation. Component of a complex that contains at least FER, CTTN and PTK2/FAK1.
Molecular function
Kinase, Transferase, Tyrosine-protein kinase
More Types Infomation
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, WB
- Mouse Anti-FER Recombinant Antibody (VS3-WK812) (VS3-WK812)
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- Derivation: Mouse
- Species Reactivity: Mouse
- Type: Mouse IgG2a, κ
- Application: WB, ICC, FC
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- Derivation: Mouse
- Species Reactivity: Human, Mouse
- Type: Mouse IgG1, κ
- Application: WB, IHC
- Mouse Anti-FER Recombinant Antibody (VS3-CJ704) (VS3-CJ704)
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- Species Reactivity: Human, Mouse
- Type: Mouse IgG1, κ
- Application: WB, IHC
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- Species Reactivity: Human, Mouse
- Type: Mouse IgG
- Application: WB, IHC, IF, ELISA
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, IHC, ICC
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For Research Use Only. Not For Clinical Use.